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Efficacy of tenofovir in patients with Lamivudine failure is not different from that in nucleoside/nucleotide analogue-naive patients with chronic hepatitis B
- Source :
- Antimicrobial agents and chemotherapy. 57(4)
- Publication Year :
- 2013
-
Abstract
- We evaluated the efficacy of tenofovir disoproxil fumarate (TDF) in patients with lamivudine failure (LAM-F) in comparison with that in nucleoside/nucleotide analogue (NA)-naïve patients with chronic hepatitis B (CHB). The criteria for inclusion were being NA naïve or having previous LAM-F and receiving TDF therapy for at least 6 months. Biochemical and virological tests were performed at the baseline, at 3-month intervals in the first year, and every 6 months thereafter. The primary outcome measure for efficacy was a complete virological response (CVR), defined as an HBV DNA level of P = 0.10) and HBeAg-positive patients (67% versus 83% at month 36, P = 0.48). According to the multivariate Cox regression model, only HBeAg positivity (hazard ratio [HR], 0.39; 95% confidence interval [CI], 0.26 to 0.59; P < 0.001) and a high baseline HBV DNA level (HR, 0.44; 95% CI, 0.29 to 0.67; P < 0.001) had a significant influence on the time to a CVR. The similar cumulative CVR rates during the follow-up show that TDF has comparable efficacy in lamivudine-experienced and NA-naïve patients, and the presence of resistance mutations did not alter the response rates.
- Subjects :
- Adult
Male
medicine.medical_specialty
Anti-HIV Agents
Organophosphonates
Pharmacology
Gastroenterology
Antiviral Agents
Hepatitis B, Chronic
Internal medicine
medicine
Humans
Pharmacology (medical)
Tenofovir
Retrospective Studies
business.industry
Proportional hazards model
Nucleotides
Adenine
Hazard ratio
Lamivudine
Retrospective cohort study
Nucleosides
Hepatitis B
Middle Aged
medicine.disease
Confidence interval
Infectious Diseases
HBeAg
Female
business
Nucleoside
medicine.drug
Subjects
Details
- ISSN :
- 10986596
- Volume :
- 57
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Antimicrobial agents and chemotherapy
- Accession number :
- edsair.doi.dedup.....ada8c819c27cae805521f0e78de557ee