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Effect of flapless osteoperforation-assisted tooth movement on atrophic alveolar ridge: Histomorphometric and gene-enrichment analysis
- Source :
- Angle Orthod
- Publication Year :
- 2017
- Publisher :
- The Angle Orthodontist (EH Angle Education & Research Foundation), 2017.
-
Abstract
- Objective: To investigate the effect of flapless osteoperforation on the tissue response of the atrophic alveolar ridge affected by orthodontic tooth movement (OTM). Materials and Methods: An atrophic alveolar ridge model was established in the mandibular quadrants of eight beagle dogs. As a split-mouth design, the quadrants were randomly divided into group C (OTM only) and group OP (OTM with flapless osteoperforation). The rate of OTM for 10 weeks was compared between groups, and micro-CT-based histomorphometric analysis and RNA-sequencing-based gene-enrichment analysis were performed targeting the atrophic ridge. Results: Group OP displayed more rapid tooth movement with lower bone mineral density and higher trabecular fraction in the atrophic ridge than did group C, showing no intergroup difference of total ridge volume. As contributing biological functional pathways in group OP, the genes related to osteoclast differentiation and TNF signaling pathway were up-regulated and those associated with Wnt signaling pathway and AMPK signaling pathway were down-regulated. Conclusions: Flapless osteoperforation facilitated the rate of OTM toward the atrophic ridge, maintaining low bone density, whereas it did not increase the volume of the atrophic ridge.
- Subjects :
- 0301 basic medicine
Tooth Movement Techniques
Alveolar Bone Loss
Osteoclasts
Dentistry
Orthodontics
Mandible
AMP-Activated Protein Kinases
Beagle
03 medical and health sciences
Dogs
0302 clinical medicine
Bone Density
Osteoclast
Alveolar Process
medicine
Alveolar ridge
Animals
Wnt Signaling Pathway
Bone mineral
Tnf signaling
Tumor Necrosis Factor-alpha
business.industry
Cell Differentiation
X-Ray Microtomography
Original Articles
030206 dentistry
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
Gene Enrichment
Tooth movement
Ridge (meteorology)
Bone Remodeling
Atrophy
business
Signal Transduction
Subjects
Details
- ISSN :
- 19457103 and 00033219
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- The Angle Orthodontist
- Accession number :
- edsair.doi.dedup.....ad9ac4261418d4b84f4ac5311db6cf04