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BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids
- Source :
- Molecular Psychiatry, Molecular Psychiatry, Nature Publishing Group, 2014, 19 (9), pp.1001-1009. ⟨10.1038/mp.2013.134⟩
- Publication Year :
- 2014
- Publisher :
- HAL CCSD, 2014.
-
Abstract
- International audience; Activation of glucocorticoid receptors (GR) by glucocorticoid hormones (GC) enhances contextual fear memories through the activation of the Erk1/2(MAPK) signaling pathway. However, the molecular mechanism mediating this effect of GC remains unknown. Here we used complementary molecular and behavioral approaches in mice and rats and in genetically modified mice in which the GR was conditionally deleted (GR(NesCre)). We identified the tPA-BDNF-TrkB signaling pathway as the upstream molecular effectors of GR-mediated phosphorylation of Erk1/2(MAPK) responsible for the enhancement of contextual fear memory. These findings complete our knowledge of the molecular cascade through which GC enhance contextual fear memory and highlight the role of tPA-BDNF-TrkB-Erk1/2(MAPK) signaling pathways as one of the core effectors of stress-related effects of GC.
- Subjects :
- Male
MESH: Hippocampus
MESH: Receptors, Glucocorticoid
[SDV]Life Sciences [q-bio]
MESH: Fear
Hippocampus
MESH: Rats, Sprague-Dawley
Tropomyosin receptor kinase B
MESH: Brain-Derived Neurotrophic Factor
Rats, Sprague-Dawley
Tissue Culture Techniques
0302 clinical medicine
Glucocorticoid receptor
MESH: Tissue Plasminogen Activator
MESH: Animals
MESH: Memory
Phosphorylation
Receptor
ComputingMilieux_MISCELLANEOUS
0303 health sciences
tissue plasminogen activator
contextual fear memory
glucocorticoids
MESH: Receptor, trkB
brain-derived neurotrophic factor
MESH: Stress, Psychological
Fear
Psychiatry and Mental health
Original Article
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Signal transduction
Psychology
MESH: Mice, Transgenic
MAP Kinase Signaling System
Transgene
Mice, Transgenic
03 medical and health sciences
Cellular and Molecular Neuroscience
Receptors, Glucocorticoid
MESH: Mice, Inbred C57BL
Memory
Animals
Receptor, trkB
MESH: Tissue Culture Techniques
tropomyosin-related kinase B
Molecular Biology
extracellular signal-regulated kinases 1/2 mitogen-activated protein kinase
030304 developmental biology
Brain-derived neurotrophic factor
MESH: Phosphorylation
MESH: MAP Kinase Signaling System
[SCCO.NEUR]Cognitive science/Neuroscience
MESH: Male
Mice, Inbred C57BL
Neuroscience
Stress, Psychological
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 13594184 and 14765578
- Database :
- OpenAIRE
- Journal :
- Molecular Psychiatry, Molecular Psychiatry, Nature Publishing Group, 2014, 19 (9), pp.1001-1009. ⟨10.1038/mp.2013.134⟩
- Accession number :
- edsair.doi.dedup.....ad88ff5dd473f49b2f6ae7ffa003fed6