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Intractable Tuberculous Meningitis With Paradoxical Reactions Treated by Anti–Tissue Necrosis Factor-α Therapy
- Source :
- Neurol Clin Pract
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Paradoxical reactions during the treatment of tuberculous meningitis indicate the worsening of pre-existing tuberculous lesions or the appearance of new tuberculous lesions in patients who initially showed improvement after anti-tuberculosis treatment.1 High-dose corticosteroid therapy is the most preferred first-line treatment, but there is no definite consensus on the management of paradoxical reactions when corticosteroids have failed. Here, we report successful treatment of a tuberculosis meningitis patient with corticosteroid-refractory paradoxical reaction using anti-tissue necrosis factor α (anti-TNF-α) therapy.
Details
- ISSN :
- 21630933 and 21630402
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Neurology: Clinical Practice
- Accession number :
- edsair.doi.dedup.....ad7bc4fb1d51d3d25d283d177604145d