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Localization of mRNAs for phosphatidylinositol phosphate kinases in the mouse brain during development
- Source :
- Gene Expression Patterns. 1:123-133
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- The gene expression for seven phosphatidylinositol phosphate kinases (PIPKs)-types Ialpha, Ibeta, Igamma, types IIalpha, IIbeta, IIgamma, and type III-was examined using in situ hybridization histochemistry, in the mouse brain during normal development. In the embryonic mouse brain, positive expression signals were detected only for the genes encoding PIPK Igamma and PIPK IIbeta in both the cerebral ventricular and mantle zones, with weaker signals in the former zone. On the other hand, the genes encoding all PIPKs were essentially detected in the external granule cell layer which represents the germinal zone for the neuronal granule cells. In the postnatal brain, among the seven PIPKs, the expression for genes encoding PIPK Igamma and IIbeta is evident in most gray matter, while the expression for the other five types was weak in the cortical gray matter and negligible in most non-cortical gray matter such as the diencephalon and brain stem nuclei. While the expression for most PIPKs in the mature hippocampus was distinct, the expression in the CA3 and the dentate gyrus was less definite for the genes encoding PIPK Ialpha and IIgamma, respectively. The distinct expression for the gene encoding PIPK IIalpha was detected in the postnatal white matter such as the cerebellar medulla, the corpus callosum, the hippocampal fimbriae, and the internal capsule.
- Subjects :
- DNA, Complementary
Time Factors
In situ hybridization
Hippocampal formation
Biology
Hippocampus
White matter
Mice
Gene expression
Genetics
medicine
Animals
Protein Isoforms
Tissue Distribution
RNA, Messenger
Molecular Biology
In Situ Hybridization
Mice, Inbred BALB C
Messenger RNA
Dentate gyrus
Brain
Anatomy
Blotting, Northern
Granule cell
Cell biology
Phosphotransferases (Alcohol Group Acceptor)
medicine.anatomical_structure
Phosphatidylinositol phosphate kinases
Brain Stem
Developmental Biology
Subjects
Details
- ISSN :
- 1567133X
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- Gene Expression Patterns
- Accession number :
- edsair.doi.dedup.....ad74dce8b07c2986ac93aeb4b5366b6b