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Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT7 receptor
- Source :
- Bioorganic & Medicinal Chemistry Letters. 15:747-750
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- The synthesis of novel C6-aryl substituted derivatives of 3-(dimethylamino)chroman is described. The novel derivatives display 5-HT(7) receptor affinities that varies from nM to muM, indicating that this small set of derivatives constitute a novel and interesting starting point for further structure-serotonin 5-HT(7) activity relationship (SAR) studies.
- Subjects :
- Models, Molecular
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Biochemistry
Chemical synthesis
5-HT7 receptor
Radioligand Assay
Structure-Activity Relationship
Drug Discovery
Humans
Structure–activity relationship
Chromans
Binding site
Receptor
Molecular Biology
Binding Sites
Molecular Structure
Chemistry
Organic Chemistry
General Medicine
Affinities
Serotonin Receptor Agonists
Receptors, Serotonin
Molecular Medicine
Serotonin
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....ad6f2b22e2e75b33368301ee1a5700ad
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.11.013