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Neural correlates of naming errors across different neurodegenerative diseases: An FDG-PET study
- Source :
- Neurology. 95(20)
- Publication Year :
- 2020
-
Abstract
- ObjectiveTo investigate the types of errors produced in a picture naming task by patients with neurodegenerative dementia due to different etiologies and their neural correlates.MethodsThe same standardized picture naming test was administered to a consecutive sample of patients (n = 148) who had been studied with [18F] FDG-PET. The errors were analyzed in 3 categories (visual, semantic, and phonologic). The PET data were analyzed using an optimized single-subject procedure, and the statistical parametric mapping multiple regression design was used to explore the correlation between each type of error and brain hypometabolism in the whole group. Metabolic connectivity analyses were run at the group level on 7 left hemisphere cortical areas corresponding to an a priori defined naming network.ResultsSemantic errors were predominant in most patients, independent of clinical diagnosis. In the whole group analysis, visual errors correlated with hypometabolism in the right inferior occipital lobe and in the left middle occipital lobe. Semantic errors correlated with hypometabolism in the left fusiform gyrus, the inferior and middle temporal gyri, and the temporal pole. Phonologic errors were associated with hypometabolism in the left superior and middle temporal gyri. Both positive (occipital–posterior fusiform) and negative (anterior fusiform gyrus and the superior anterior temporal lobe) connectivity changes were associated with semantic errors.ConclusionsNaming errors reflect the dysfunction of separate stages of the naming process and are specific markers for different patterns of brain involvement. These correlations are not limited to primary progressive aphasia but extend to other neurodegenerative dementias.
- Subjects :
- Male
medicine.medical_specialty
Audiology
Statistical parametric mapping
050105 experimental psychology
Lateralization of brain function
Temporal lobe
neuroscience
Primary progressive aphasia
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Fluorodeoxyglucose F18
Aphasia
medicine
Connectome
Humans
Speech
0501 psychology and cognitive sciences
Aged
Language
Retrospective Studies
Aged, 80 and over
Neural correlates of consciousness
Fusiform gyrus
business.industry
05 social sciences
Neurodegenerative Diseases
medicine.disease
Temporal Lobe
image processing
Semantics
PET
Aphasia, Primary Progressive
Pattern Recognition, Visual
Frontotemporal Dementia
Positron-Emission Tomography
Dementia
Female
Neurology (clinical)
Occipital Lobe
Supranuclear Palsy, Progressive
medicine.symptom
Occipital lobe
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1526632X
- Volume :
- 95
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....ad6cf8885c375ef34b611641d3afc105