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On-Site and Quantitative Detection of Trace Methamphetamine in Urine/Serum Samples with a Surface-Enhanced Raman Scattering-Active Microcavity and Rapid Pretreatment Device
- Source :
- Analytical Chemistry. 92:13539-13549
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- Here, it reports a high-throughput detection method for reliably quantitative analysis of illegal drugs in complex biological samples by means of a surface-enhanced Raman scattering (SERS) active microcavity and rapid pretreatment device. Based on the well-made hemispherical microcavities that regularly distributed on a glass array, the quality-controllable microcavity device is fabricated by the compact self-assembly of core-shell nanopeanuts (CSNPs) onto the inside surface. Both the CSNPs with a quantifiable internal standard signal of crystal violet acetate anchored inside their gap and the well-made microcavity referred to the physical amplification of the microscale groove surface will do well in trace analysis, which will allow us to realize the accurately quantitative SERS analysis of targeted analytes spread on the bottom area of the microcavity array. As an example, 0.8 nM malachite green and 160 ppb methamphetamine (MATM) have been successively detected in a wide range as standard, while even 0.01 ppm MATM mixed in the urine/serum samples has been efficiently tested by the microcavity device equipped with a rapid pretreatment device (manual monolithic column syringe needle). All of the above suggest that the SERS-active microcavity equipped with a rapid pretreatment device has potential in the on-site quick test of trace amounts of illegal drugs in bodily fluid samples or other field analysis of food sanitation, environmental safety, and public health.
- Subjects :
- Analyte
Monolithic HPLC column
Trace Amounts
Surface Properties
Metal Nanoparticles
Spectrum Analysis, Raman
010402 general chemistry
01 natural sciences
Methamphetamine
Analytical Chemistry
symbols.namesake
chemistry.chemical_compound
Humans
Crystal violet
Microscale chemistry
Chemistry
business.industry
010401 analytical chemistry
0104 chemical sciences
symbols
Optoelectronics
Gold
business
Raman spectroscopy
Quantitative analysis (chemistry)
Raman scattering
Subjects
Details
- ISSN :
- 15206882 and 00032700
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Analytical Chemistry
- Accession number :
- edsair.doi.dedup.....ad5539078ed9868136507baf84241b7f