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Dynamic tracking of functional gene modules in treated juvenile idiopathic arthritis
- Source :
- Genome Medicine
- Publication Year :
- 2015
- Publisher :
- BioMed Central, 2015.
-
Abstract
- Background We have previously shown that childhood-onset rheumatic diseases show aberrant patterns of gene expression that reflect pathology-associated co-expression networks. In this study, we used novel computational approaches to examine how disease-associated networks are altered in one of the most common rheumatic diseases of childhood, juvenile idiopathic arthritis (JIA). Methods Using whole blood gene expression profiles derived from children in a pediatric rheumatology clinical trial, we used a network approach to understanding the impact of therapy and the underlying biology of response/non-response to therapy. Results We demonstrate that therapy for JIA is associated with extensive re-ordering of gene expression networks, even in children who respond inadequately to therapy. Furthermore, we observe distinct differences in the evolution of specific network properties when we compare children who have been treated successfully with those who have inadequate treatment response. Conclusions Despite the inherent noisiness of whole blood gene expression data, our findings demonstrate how therapeutic response might be mapped and understood in pathologically informative cells in a broad range of human inflammatory diseases.
- Subjects :
- Male
Adolescent
Systems biology
Drug Resistance
Arthritis
Etanercept
03 medical and health sciences
0302 clinical medicine
Prednisone
Gene expression
Genetics
Medicine
Humans
Genetics(clinical)
Child
Molecular Biology
Genetics (clinical)
030304 developmental biology
030203 arthritis & rheumatology
0303 health sciences
business.industry
Sequence Analysis, RNA
Research
medicine.disease
Human genetics
Arthritis, Juvenile
3. Good health
Clinical trial
Methotrexate
Antirheumatic Agents
Child, Preschool
Immunology
Molecular Medicine
Female
business
Transcriptome
Rheumatism
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 1756994X
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Genome Medicine
- Accession number :
- edsair.doi.dedup.....ad4a963c448eb282cad97cdff613383e