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Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin
- Source :
- Doklady Biochemistry and Biophysics. 464:341-345
- Publication Year :
- 2015
- Publisher :
- Pleiades Publishing Ltd, 2015.
-
Abstract
- The ability of SkQ1 eye drops to slow down the cataract development is demonstrated on the senescence-accelerated OXYS rats: the SkQ1 treatment leads to the considerable improvement of the lens condition as compared to the control group. The comparison of the chaperone activities of α-crystallins isolated from the rat lenses did not reveal significant difference between SkQ1-treated and control rats. The contents of major metabolites (23 compounds) in lenses of SkQ1-treated and untreated rats are also very similar, though the concentration of reduced glutathione (GSH) in lenses of SkQ1-treated rats is 12% lower. This difference may be attributed to the reduction of the oxidative stress under action of SkQ1 eye drops, and to the decreased requirement to produce high amounts of this antioxidant.
- Subjects :
- Aging
medicine.medical_specialty
Antioxidant
Rat lens
genetic structures
Plastoquinone
medicine.medical_treatment
Biophysics
medicine.disease_cause
Biochemistry
Cataract
law.invention
chemistry.chemical_compound
Metabolomics
law
Crystallin
Internal medicine
Lens, Crystalline
medicine
Animals
alpha-Crystallins
biology
Free Radical Scavengers
General Chemistry
General Medicine
Glutathione
beta-Crystallins
eye diseases
Rats
Lens (optics)
Disease Models, Animal
Kinetics
Oxidative Stress
Endocrinology
chemistry
Chaperone (protein)
biology.protein
sense organs
Ophthalmic Solutions
Protein Multimerization
Oxidative stress
Subjects
Details
- ISSN :
- 16083091 and 16076729
- Volume :
- 464
- Database :
- OpenAIRE
- Journal :
- Doklady Biochemistry and Biophysics
- Accession number :
- edsair.doi.dedup.....ad44906ca6b0716e3e91fe649e94cef7