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Serum interleukin-6 and tumor necrosis factor-α are associated with early graft regeneration after living donor liver transplantation
- Source :
- PLoS ONE, Vol 13, Iss 4, p e0195262 (2018), PLoS ONE
- Publication Year :
- 2018
- Publisher :
- Public Library of Science (PLoS), 2018.
-
Abstract
- Background Liver graft regeneration is orchestrated by specific and sequential stimuli, including hepatocyte growth factors, cytokines, and catecholamines. We evaluated the association between preoperative serum cytokines and early liver graft regeneration in human living donor liver transplantation (LDLT). Patients and methods We retrospectively reviewed the data of adult patients who underwent LDLT from January 2010 to December 2014. Serum cytokines, including interleukin (IL)-2, 6, 10, 12, 17, interferon (IFN)-γ and tumor necrosis factor (TNF)-α were measured in the recipients 1 day before surgery and on postoperative day (POD) 7. Liver graft volume was estimated using abdominal computed tomography images of the donors and recipients. Results In total, 226 patients were analyzed in this study. Median preoperative levels of serum cytokines were as follows: IL-2, 0.1 (0.1–1.6) pg/mL; IL-6, 7.3 (0.1–30.2) pg/mL; IL-10, 0.5 (0.1–11.0) pg/mL; IL-12, 0.1 (0.1–0.1) pg/mL; IL-17, 2.0 (0.1–16.4) pg/mL; IFN-γ, 3.2 (0.1–16.0) pg/mL; and TNF-α, 9.8 (5.4–17.9) pg/mL. Higher preoperative serum levels of IL-6, IL-10, and TNF-α, dichotomized at the median, were associated with increased relative liver volumes by POD 7. Multivariate analysis revealed that higher levels of serum IL-6 and TNF-α were independently associated with increased graft volume during the first 1 week after LDLT, based on the lower levels of those cytokines. Conclusions IL-6 and TNF-α were important mediators of the success of early graft regeneration in patients who underwent LDLT.
- Subjects :
- Male
0301 basic medicine
Time Factors
Physiology
medicine.medical_treatment
lcsh:Medicine
Liver transplantation
Gastroenterology
0302 clinical medicine
Animal Cells
Interferon
Immune Physiology
Neurobiology of Disease and Regeneration
Living Donors
Medicine and Health Sciences
Morphogenesis
Postoperative Period
lcsh:Science
Innate Immune System
Multidisciplinary
biology
Liver Diseases
Fatty liver
Living-Related Liver Transplantation
Interleukin
Middle Aged
Liver regeneration
medicine.anatomical_structure
Neurology
Liver
Hepatocyte
Preoperative Period
Cytokines
Female
030211 gastroenterology & hepatology
Tumor necrosis factor alpha
Cellular Types
Anatomy
Research Article
medicine.drug
medicine.medical_specialty
Immunology
Surgical and Invasive Medical Procedures
Gastroenterology and Hepatology
Digestive System Procedures
03 medical and health sciences
Internal medicine
medicine
Humans
Regeneration
Interleukin 6
Retrospective Studies
Transplantation
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
lcsh:R
Biology and Life Sciences
Organ Transplantation
Cell Biology
Molecular Development
medicine.disease
Liver Regeneration
Liver Transplantation
Fatty Liver
030104 developmental biology
Immune System
Hepatocytes
biology.protein
lcsh:Q
business
Organism Development
Developmental Biology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....ad405539a1fec5f7f92a0865e2fca6b0