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Cullin-Ring ubiquitin ligases in kidney health and disease
- Source :
- Curr Opin Nephrol Hypertens
- Publication Year :
- 2019
-
Abstract
- 1. PURPOSE OF REVIEW: Members of the Cullin family act as scaffolds in E3 ubiquitin ligases and play a central role in mediating protein degradation. Interactions with many different substrate-binding adaptors permit Cullin-containing E3 ligases to participate in diverse cellular functions. In the kidney, one well-established target of Cullin-mediated degradation is the transcription factor Nrf2, a key player in responses to oxidative stress. The goal of this review is to discuss more recent findings revealing broader roles for Cullins in the kidney. 2. RECENT FINDINGS: Cullin 3 acts as the scaffold in the E3 ligase regulating Nrf2 abundance, but was more recently shown to be mutated in the disease Familial Hyperkalemic Hypertension. Studies seeking to elucidate the molecular mechanisms by which Cullin 3 mutations lead to dysregulation of renal sodium transport will be discussed. Disruption of Cullin 3 in mice unexpectedly causes polyuria and fibrotic injury suggesting it has additional roles in the kidney. We will also review recent transcriptomic data suggest that other Cullins are also likely to play important roles in renal function. 3. SUMMARY: Cullins form a large and diverse family of E3 ubiquitin ligases that are likely to have many important functions in the kidney.
- Subjects :
- NF-E2-Related Factor 2
Pseudohypoaldosteronism
Ubiquitin-Protein Ligases
030232 urology & nephrology
macromolecular substances
030204 cardiovascular system & hematology
Protein degradation
Kidney
Article
Transcriptome
03 medical and health sciences
0302 clinical medicine
Ubiquitin
Internal Medicine
medicine
Animals
Humans
Transcription factor
Carcinoma, Renal Cell
Adaptor Proteins, Signal Transducing
biology
fungi
Microfilament Proteins
Signal transducing adaptor protein
Cullin Proteins
Sodium Chloride Symporters
Kidney Neoplasms
Cell biology
Ubiquitin ligase
enzymes and coenzymes (carbohydrates)
medicine.anatomical_structure
Nephrology
embryonic structures
biology.protein
Kidney Diseases
Cullin
Subjects
Details
- ISSN :
- 14736543
- Volume :
- 28
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Current opinion in nephrology and hypertension
- Accession number :
- edsair.doi.dedup.....ad2abe4fbfc6cc000e9c692802ee87ec