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Effect of Charcoal and Sorbitol-Charcoal Suspension on the Elimination of Intravenous Phenobarbital

Effect of Charcoal and Sorbitol-Charcoal Suspension on the Elimination of Intravenous Phenobarbital

Authors :
Mary J. Berg
Richard W. Fincham
Dale Eric Wurster
James Q. Rose
Dorothy D. Schottelius
Shaila Rahman
Source :
Therapeutic Drug Monitoring. 9:41-47
Publication Year :
1987
Publisher :
Ovid Technologies (Wolters Kluwer Health), 1987.

Abstract

The effects of two different oral charcoal suspensions on the elimination of a 200 mg/70 kg, 1 h intravenous (i.v.) infusion of phenobarbital and the tolerances of the two regimens were determined in a randomized crossover study in six healthy male volunteers. Phenobarbital was given i.v. alone or together with 105 g of oral activated charcoal suspension or with 105 g of a commercially available sorbitol-charcoal suspension over a 36-h period. A 13-34% decrease in the area under the serum concentration time curve (AUC) for 0-60 h occurred with the administration of the activated charcoal, and a 19-52% decrease occurred with the commercial sorbitol-charcoal regimen. The mean apparent systemic clearance of total phenobarbital increased from 0.089 +/- 0.019 ml/min/kg to 0.141 +/- 0.029 and 0.146 +/- 0.036 ml/min/kg with the charcoal and sorbitol-charcoal treatments, respectively. No significant change in the fraction of phenobarbital bound to protein was detected. The charcoal regimen caused constipation in one subject. All subjects taking the sorbitol-charcoal preparation experienced diarrhea; there were no changes in electrolytes with either charcoal suspension. All subjects preferred the sorbitol-charcoal preparation.

Details

ISSN :
01634356
Volume :
9
Database :
OpenAIRE
Journal :
Therapeutic Drug Monitoring
Accession number :
edsair.doi.dedup.....ad1fb6ed851115a23b36b7b740688865
Full Text :
https://doi.org/10.1097/00007691-198703000-00008