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The possible roles of B-cell novel protein-1 (BCNP1) in cellular signalling pathways and in cancer
- Source :
- Journal of Cellular and Molecular Medicine
- Publication Year :
- 2016
-
Abstract
- B‐cell novel protein‐1 (BCNP1) or Family member of 129C (FAM129C) was identified as a B‐cell‐specific plasma‐membrane protein. Bioinformatics analysis predicted that BCNP1 might be heavily phosphorylated. The BCNP1 protein contains a pleckstrin homology (PH) domain, two proline‐rich (PR) regions and a Leucine Zipper (LZ) domain suggesting that it may be involved in protein‐protein interactions. Using The Cancer Genome Atlas (TCGA) data sets, we investigated the correlation of alteration of the BCNP1 copy‐number changes and mutations in several cancer types. We also investigated the function of BCNP1 in cellular signalling pathways. We found that BCNP1 is highly altered in some types of cancers and that BCNP1 copy‐number changes and mutations co‐occur with other molecular alteration events for TP53 (tumour protein P53), PIK3CA (Phosphatidylinositol‐4,5‐Bisphosphate 3‐Kinase, Catalytic Subunit Alpha), MAPK1 (mitogen‐activated protein kinase‐1; ERK: extracellular signal regulated kinase), KRAS (Kirsten rat sarcoma viral oncogene homolog) and AKT2 (V‐Akt Murine Thymoma Viral Oncogene Homolog 2). We also found that PI3K (Phoshoinositide 3‐kinase) inhibition and p38 MAPK (p38 mitogen‐activated protein kinase) activation leads to reduction in phosphorylation of BCNP1 at serine residues, suggesting that BCNP1 phosphorylation is PI3K and p38MAPK dependent and that it might be involved in cancer. Its degradation depends on a proteasome‐mediated pathway.
- Subjects :
- 0301 basic medicine
MAPK/ERK pathway
Leucine zipper
Cell signaling
DNA Copy Number Variations
Class I Phosphatidylinositol 3-Kinases
Protein subunit
AKT2
Biology
p38 MAPK
p38 Mitogen-Activated Protein Kinases
Cell Line
Proto-Oncogene Proteins p21(ras)
03 medical and health sciences
Phosphatidylinositol 3-Kinases
Neoplasms
Humans
Phosphorylation
Protein kinase A
Mitogen-Activated Protein Kinase 1
phoshoinositide 3‐kinase
Membrane Proteins
Cell Biology
Original Articles
bioinformatics
Cell biology
Neoplasm Proteins
Pleckstrin homology domain
030104 developmental biology
HEK293 Cells
Mutation
Molecular Medicine
Original Article
family member of 129C
Tumor Suppressor Protein p53
Apoptosis Regulatory Proteins
Proto-Oncogene Proteins c-akt
Signal Transduction
B‐cell novel protein‐1
Subjects
Details
- ISSN :
- 15824934
- Volume :
- 21
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of cellular and molecular medicine
- Accession number :
- edsair.doi.dedup.....ad0edbf73c23943263259262be8ba7ac