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Persistent Alanine Aminotransferase Elevation in Healthy Swedish Blood Donors - Mainly Caused by Obesity
- Source :
- Vox Sanguinis. 55:152-156
- Publication Year :
- 1988
- Publisher :
- Wiley, 1988.
-
Abstract
- Five hundred consecutive healthy blood donors were tested for serum alanine aminotransferase (ALT) and 44 (8.8%) had increased levels. Donors with and without raised ALT were compared in several aspects but only weight (expressed as percentage of ideal body weight) and sex differed significantly (119.1 +/- 14.5 and 106.3 +/- 12.8%, respectively; p less than 0.001 and males 97.7 and 77.1%, respectively; p less than 0.01). The 44 donors with raised ALT were followed up and in 13 out of 15 donors with persistently raised ALT without obvious reason, a liver biopsy was performed. Ten donors had various degrees of liver steatosis, 2 had normal liver morphology and in 1 donor chronic hepatitis could not be ruled out. If ALT screening is introduced as a surrogate test for non-A, non-B hepatitis in Swedish blood donors, we suggest that a correction for overweight must be considered in order to minimize donor loss.
- Subjects :
- Adult
Male
Liver morphology
medicine.medical_specialty
Adolescent
Blood Donors
Overweight
Body weight
Gastroenterology
Liver steatosis
Internal medicine
medicine
Humans
Obesity
Alanine aminotransferase
Aged
Sweden
Hepatitis
medicine.diagnostic_test
business.industry
Alanine Transaminase
Hematology
General Medicine
Middle Aged
medicine.disease
Surgery
Liver biopsy
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 14230410 and 00429007
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Vox Sanguinis
- Accession number :
- edsair.doi.dedup.....ad0cf730185a8a13320ce572246feac9