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Current Data Regarding the Relationship between Type 2 Diabetes Mellitus and Cardiovascular Risk Factors
- Source :
- Diagnostics, Diagnostics, Vol 10, Iss 314, p 314 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Reducing cardiovascular risk (CVR) is the main focus of diabetes mellitus (DM) management nowadays. Complex pathogenic mechanisms that are the subject of this review lead to early and severe atherosclerosis in DM patients. Although it is not a cardiovascular disease equivalent at the moment of diagnosis, DM subjects are affected by numerous cardiovascular complications, such as acute coronary syndrome, stroke, or peripheral artery disease, as the disease duration increases. Therefore, early therapeutic intervention is mandatory and recent guidelines focus on intensive CVR factor management: hyperglycaemia, hypertension, and dyslipidaemia. Most important, the appearance of oral or injectable antidiabetic medication such as SGLT-2 inhibitors or GLP-1 agonists has proven that an antidiabetic drug not only reduces glycaemia, but also reduces CVR by complex mechanisms. A profound understanding of intimate mechanisms that generate atherosclerosis in DM and ways to inhibit or delay them are of the utmost importance in a society where cardiovascular morbidity and mortality are predominant.
- Subjects :
- cardiovascular risk
Drug
Acute coronary syndrome
medicine.medical_specialty
media_common.quotation_subject
Clinical Biochemistry
Cardiovascular risk factors
030209 endocrinology & metabolism
Review
Disease
030204 cardiovascular system & hematology
pathogenic mechanisms
03 medical and health sciences
0302 clinical medicine
Intervention (counseling)
Diabetes mellitus
Medicine
Intensive care medicine
Stroke
media_common
lcsh:R5-920
diabetes
GLP-1 agonists
business.industry
SGLT-2 inhibitors
Type 2 Diabetes Mellitus
medicine.disease
lcsh:Medicine (General)
business
Subjects
Details
- ISSN :
- 20754418
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Diagnostics
- Accession number :
- edsair.doi.dedup.....ad0bd73a74f42266e5d14b181b7bd3ba