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Carcinosarcoma of the Pancreas
- Source :
- Pancreas. 46:1225-1233
- Publication Year :
- 2017
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2017.
-
Abstract
- Carcinosarcomas are rare biphasic neoplasms with distinct malignant epithelial and mesenchymal components. Most commonly, carcinosarcomas arise in the uterus as malignant mixed müllerian tumors, but also infrequently appear in other organs such as the ovaries and breast, the prostate and urinary tract, the lungs, or in the gastrointestinal system, among others. Pancreatic carcinosarcomas are exceedingly rare; only a few cases are reported in the English literature. Their pathogenesis remains to be fully clarified. We present here the case of a pancreatic carcinosarcoma with evidence for monoclonality via determination of Kras mutational status after microdissection and suggest a common origin of the 2 tumor components. Comprehensive review of the available literature allows the conclusion that most pancreatic carcinosarcomas appear to be of monoclonal origin and seem to have arisen from a carcinoma via metaplastic transformation of 1 part or subclone of the tumor, probably by epithelial-mesenchymal transition. All reported patients were treated with surgery. Adjuvant therapy, if administered, consisted predominantly of gemcitabine. Prognosis for this neoplasm occurs to be similar or even worse compared with classic pancreatic ductal adenocarcinoma. Despite the lack of evidence-based recommendations for its treatment, resection should be performed, if possible.
- Subjects :
- Pathology
medicine.medical_specialty
CA-19-9 Antigen
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
medicine.disease_cause
Pancreaticoduodenectomy
03 medical and health sciences
Fatal Outcome
0302 clinical medicine
Endocrinology
Carcinoembryonic antigen
Carcinosarcoma
Biomarkers, Tumor
Internal Medicine
Adjuvant therapy
Carcinoma
Humans
Medicine
Pancreas
Microdissection
Aged
Hepatology
biology
business.industry
medicine.disease
Carcinoembryonic Antigen
Pancreatic Neoplasms
medicine.anatomical_structure
030220 oncology & carcinogenesis
biology.protein
Female
030211 gastroenterology & hepatology
KRAS
business
Subjects
Details
- ISSN :
- 15364828 and 08853177
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Pancreas
- Accession number :
- edsair.doi.dedup.....ad06e3a60b5c2a9b6e5664b44cc3cf5f