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Serotonin toxicity: a short review of the literature and two case reports involving Citalopram
- Source :
- Neurological Sciences. 32:507-509
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- The serotonin toxicity (ST) is a potentially life-threatening adverse drug reaction results from therapeutic drug use, intentional self-poisoning, or inadvertent interactions between drugs. ST can be caused by a single or a combination of drugs with serotonergic activity due to excessive serotonergic agonism on central nervous system and peripheral serotonergic receptors (monoamine oxidase inhibitors, tricyclic antidepressants, SSRIs, opiate analgesics, over-the-counter cough medicines, antibiotics, weight-reduction agents, antiemetics, antimigraine agents, drugs of abuse, H2-antagonist and herbal products). The serotonin toxicity is often described as a clinical triad of mental-status changes (agitation and excitement with confusion), autonomic hyperactivity (diaphoresis, fever, tachycardia, and tachypnea), neuromuscular abnormalities (tremor, clonus, myoclonus, and hyperreflexia) and, in the advanced stage, spasticity; not all of these findings are consistently present. In this article, we describe two cases of ST due to interaction between Citalopram and two CYP2D6 inhibitors: Cimetidine and Topiramate and their clinical resolution after treatment discontinuation.
- Subjects :
- Male
Topiramate
Serotonin Syndrome
Fructose
Dermatology
Citalopram
Pharmacology
Serotonergic
Serotonin syndrome
Cytochrome P-450 CYP2D6 Inhibitors
medicine
Humans
Serotonin Uptake Inhibitors
malignant syndrome
citalopram
cimetidine
serotonin toxicity
topiramate
neuroleptic
drug interaction
Aged
business.industry
General Medicine
Drug interaction
medicine.disease
Psychiatry and Mental health
Cytochrome P-450 CYP2D6
Anesthesia
Female
Neurology (clinical)
Serotonin
medicine.symptom
Cimetidine
business
Selective Serotonin Reuptake Inhibitors
Adverse drug reaction
medicine.drug
Subjects
Details
- ISSN :
- 15903478 and 15901874
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Neurological Sciences
- Accession number :
- edsair.doi.dedup.....aceea6c67d1f60470be539a17640accf
- Full Text :
- https://doi.org/10.1007/s10072-011-0546-z