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Allelic Loss of Chromosome 16q in Endometrial Cancer: Correlation with Poor Prognosis of Patients and Less Differentiated Histology
- Source :
- Japanese Journal of Cancer Research : Gann
- Publication Year :
- 1996
- Publisher :
- Wiley, 1996.
-
Abstract
- Deletion of certain chromosomal regions can be demonstrated in malignant cells. Chromosome 16q is one of the regions where allelic loss is frequently detected in carcinoma of the breast and many other tumors, suggesting that gene(s) which retard tumor growth may exist here. To elucidate the clinico-pathological significance of chromosome 16q, loss of heterozygosity (LOH) was investigated using microsatellite polymorphism analysis in 58 patients with endometrial lesions (50 with endometrial carcinoma and 8 who had hyperplasia with or without atypia). When 11 regions of chromosome 16q were examined, LOH was found in 20 patients with carcinoma (40%) and none of the patients with hyperplasia. The tumors of 9 of the 20 patients (45%) showed total loss of 16q, while the others (55%) showed partial deletion. Tumors with LOH were histologically less differentiated than those without LOH (P = 0.038, x 2 test). Patients with tumors showing LOH of 16q had a worse prognosis than those without LOH according to Kaplan-Meier survival analysis (P=0.0158, log-rank test). In addition, LOH of 16q showed a significant relationship to prognosis by Cox regression analysis. Deletion mapping of 16q demonstrated that two regions (16q22.1 and 16q22.2-23.1) were frequently involved. Patients with 16q22.1 LOH had a poorer prognosis than those with intact 16q22.1 (P=0.0003, log-rank test). These findings suggest that gene(s) of which defect is possibly related to the aggressiveness of endometrial cancer are localized on a limited region of 16q that includes 16q22.1.
- Subjects :
- Heterozygote
Cancer Research
medicine.medical_specialty
Pathology
Chromosome 16q
DNA, Satellite
Biology
Polymerase Chain Reaction
Article
Loss of heterozygosity
Endometrial cancer
Carcinoma
medicine
Atypia
Humans
Deletion mapping
Alleles
Survival analysis
Prognostic factor
Cytogenetics
DNA, Neoplasm
Hyperplasia
Prognosis
medicine.disease
Endometrial Neoplasms
Oncology
Female
Chromosomes, Human, Pair 16
Gene Deletion
Subjects
Details
- ISSN :
- 09105050
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Japanese Journal of Cancer Research
- Accession number :
- edsair.doi.dedup.....ace4e60429343d8dc7d42b913decade4
- Full Text :
- https://doi.org/10.1111/j.1349-7006.1996.tb03130.x