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A Conventional New Procedure for N-Acylation of Unprotected Amino Acids
- Source :
- ChemInform. 38
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- The preparation of amide derivatives (4) by N-acylation of unprotected alpha-amino acids is easily achieved via readily available benzotriazolyl carboxylates (2a-d) or succinimidyl carboxylates (2e-f). These intermediates (2) are prepared from reaction of carboxylic acids (1) with 1-hydroxybenzotriazole (HO-Bt) or N-hydroxysuccinimide (HO-Su) in the presence of equimolar amounts of 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride (WSCI). The overall yields of the target compounds (4) were excellent, and this two-stage procedure could be applicable as an alternative procedure for one-pot reaction.
- Subjects :
- chemistry.chemical_classification
Magnetic Resonance Spectroscopy
Spectrophotometry, Infrared
Carbodiimide hydrochloride
Acylation
General Chemistry
General Medicine
Spectrometry, Mass, Fast Atom Bombardment
Amino acid
chemistry.chemical_compound
N-Hydroxysuccinimide
N acylation
chemistry
Amide
Drug Discovery
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide
Organic chemistry
Amino Acids
Subjects
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi.dedup.....ace25f276dfc1455a0eaea64753a151d
- Full Text :
- https://doi.org/10.1002/chin.200727157