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Quantification of total polyphenols, catechin, caffeine, L-theanine, determination of antioxidant activity and effect on antileishmanial drugs of ethiopian tea leaves extracts
- Source :
- Pharmacognosy Research
- Publication Year :
- 2015
- Publisher :
- Medknow Publications & Media Pvt Ltd, 2015.
-
Abstract
- Objective: In this study four tea samples Gumero black, Wushwush black and Wushwush green from Agri- Ceft Plc and East Africa black tea leaves from East African Agribusiness Plc were investigated for total polyphenols, caffeine, catechin and L-theanine content. Materials and Methods: The aqueous extracts were investigated for their antioxidant and antileishmanial property and effect on amphotericin B, miltefocine and sodium stibogluconate, the commonly used antileishmanial drugs. Antileishmanial studies were conducted on L. aethiopica . Results: Wushwush green tea had the highest content of polyphenol (19.98 ± 1.15 mg gallic acid equivalent /100 g dry leaf weight), catechin (37.06 mg/g) and L-theanine (48.54 mg/g but the lowest caffeine content). It exhibited the highest antioxidant activity. The highest antioxidant effect of Wushwush green tea may be attributed to the highest polyphenol content. East African black tea had the lowest L-theanine (20.72 mg/g) and antioxidant activity but the highest caffeine (16.60 mg/g) content. Conclusion: Wushwush green tea showed slight inhibitory effect on L. aethiopica while the lack tea extracts (Gumero, East Africa and Wushwush) exhibited no antileishmanial activity. Wushwush green tea did not show any synergistic or antagonistic effect on the antileishmanial drugs used in this study while Gumero, East Africa and Wushwush black tea extracts exhibited dose dependant inhibitory activity to the commonly used antileishmanial drugs included in this study.
- Subjects :
- Pharmacology
Antioxidant
Traditional medicine
Sodium stibogluconate
medicine.medical_treatment
food and beverages
Polyphenols
Catechin
L-theanine
Camellia sinensis
chemistry.chemical_compound
chemistry
Polyphenol
Caffeine
Drug Discovery
ANTILEISHMANIAL DRUGS
medicine
Original Article
Gallic acid
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 09748490 and 09764836
- Volume :
- 7
- Issue :
- Suppl 1
- Database :
- OpenAIRE
- Journal :
- Pharmacognosy Research
- Accession number :
- edsair.doi.dedup.....acd8614a38b6e04f682acb6ad6eedc0e