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Anti-oncogenic potential of the eIF4E-binding proteins
- Source :
- Oncogene. 32:671-677
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- The eIF4E-binding proteins (4E-BPs) are inhibitors of protein synthesis that sequester the mRNA cap-binding protein eIF4E and consequently block cell growth and proliferation. In most tumors however, their inhibitory function is compromised by major oncogenic signaling pathways. Recently, thanks to the generation of mouse genetic models, considerable progress has been made in elucidating the involvement of 4E-BPs and their unique target, eIF4E, in the process of carcinogenesis. Increasing evidence indicates that an 'addiction' to protein synthesis emerges in cancer cells, highlighting the potential that 4E-BPs have as targets for therapeutics. In this review, we summarize the biochemical function, regulation and anti-oncogenic activity of the 4E-BPs.
- Subjects :
- Cancer Research
Cell Cycle Proteins
Biology
urologic and male genital diseases
medicine.disease_cause
Genetic model
Genetics
Protein biosynthesis
medicine
Animals
Humans
Eukaryotic Initiation Factors
Phosphorylation
Cell Cycle Protein
Molecular Biology
Adaptor Proteins, Signal Transducing
Cell Proliferation
Cell growth
EIF4E
Signal transducing adaptor protein
Phosphoproteins
Cell biology
Repressor Proteins
Cell Transformation, Neoplastic
Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factor-4F
Protein Biosynthesis
Cancer cell
Carcinogenesis
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 14765594 and 09509232
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Oncogene
- Accession number :
- edsair.doi.dedup.....acc7196c9cd20ff713eb1f8da42730b6