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The Effect on Surgical Complications of Bevacizumab Added to Neoadjuvant Chemotherapy for Breast Cancer: NRG Oncology/NSABP Protocol B-40
- Source :
- Annals of surgical oncology, vol 24, iss 7
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- BackgroundNRG Oncology/NSABP trial B-40 tested the impact of adding bevacizumab (bev) to neoadjuvant chemotherapy for operable breast cancer. Secondary endpoints included rates of surgical complications after surgery in patients who did or did not receive bev.MethodsA total of 1206 women with HER2-negative operable breast cancer were randomly assigned to receive one of three different docetaxel-plus-anthracycline-based regimens, without or with bev (15mg/kg every 3weeks) for the first 6 of 8 cycles and for 10 doses postoperatively. Surgical complications were assessed from date of surgery through 24months following study entry.ResultsEarly surgical complications were significantly more frequent in the bev group (25.4 vs. 18.9%; trend test p = 0.008), but most were grade 1-2. Early noninfectious wound dehiscences were infrequent and not significantly different (5.4 vs. 3.1%; trend test p = 0.15). Long-term noninfectious wound complications were significantly higher for patients receiving bev (11.8 vs. 5.1%; trend test p = 0.0007), but the incidence of grade ≥3 wound dehiscence was low in both groups (
- Subjects :
- Oncology
Mammaplasty
medicine.medical_treatment
Docetaxel
0302 clinical medicine
Surgical oncology
Antineoplastic Combined Chemotherapy Protocols
Medicine
Anthracyclines
Prospective Studies
030212 general & internal medicine
Mastectomy
Cancer
Prognosis
Combined Modality Therapy
Bevacizumab
Survival Rate
030220 oncology & carcinogenesis
Female
Taxoids
Patient Safety
Breast reconstruction
6.4 Surgery
medicine.drug
medicine.medical_specialty
Clinical Trials and Supportive Activities
Oncology and Carcinogenesis
Breast Neoplasms
Article
03 medical and health sciences
Breast cancer
Clinical Research
Internal medicine
Breast Cancer
Humans
Surgical Wound Infection
Oncology & Carcinogenesis
Survival rate
business.industry
Wound dehiscence
Evaluation of treatments and therapeutic interventions
medicine.disease
Surgery
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15344681 and 10689265
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Annals of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....acb05b65a6664d0c605a29ca42085b45