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Effects of poloxamer-based thermo-sensitive sol-gel agent on urethral stricture after transurethral resection of the prostate for benign prostatic hyperplasia: a multicentre, single-blinded, randomised controlled trial
- Source :
- BJU internationalReferences. 125(1)
- Publication Year :
- 2019
-
Abstract
- Objective To evaluate the effectiveness of poloxamer-based thermo-sensitive sol-gel instillation, after transurethral resection of the prostate (TURP), for preventing urethral stricture. Patients and methods In all, 198 patients underwent TURP for benign prostatic hyperplasia. Recruited patients were randomly divided into two groups: groups A and B. Patients in Group A (100 patients, experimental group) received poloxamer-based thermo-sensitive sol-gel instillation and patients in the Group B (98 patients, control group) received lubricant instillation after TURP. Each patient was evaluated at 4 (V1), 12 (V2), and 24 weeks (V3) after TURP. The effectiveness of poloxamer-based thermo-sensitive sol-gel instillation was evaluated based on the International Prostate Symptom Score (IPSS), IPSS-Quality of Life (QoL), Overactive bladder questionnaire (OAB-q), maximum urinary flow rate (Qmax ), post-void residual urine volume (PVR), and cystoscopy. Results Amongst the initial 198 participants, 80 patients in Group A and 83 in Group B completed the study. There were no significant differences in IPSS-QoL and OAB-q between the groups. However, Qmax was significantly different between groups A and B, at a mean (SD) of 18.92 (9.98) vs 15.58 (9.24) mL/s (P = 0.028) at 24 weeks after TURP. On cystoscopic examination, urethral stricture after TURP was found in two of the 80 patients in Group A and 10 of 83 in Group B (P = 0.023). Conclusions Poloxamer-based thermo-sensitive sol-gel instillation after TURP lowered the incidence of urethral stricture.
- Subjects :
- Male
medicine.medical_specialty
Urethral stricture
Urology
medicine.medical_treatment
030232 urology & nephrology
Prostatic Hyperplasia
Poloxamer
urologic and male genital diseases
Group B
law.invention
03 medical and health sciences
0302 clinical medicine
Postoperative Complications
Randomized controlled trial
law
0502 economics and business
medicine
Humans
Single-Blind Method
Prospective Studies
Transurethral resection of the prostate
Aged
Urethral Stricture
medicine.diagnostic_test
business.industry
05 social sciences
Temperature
Transurethral Resection of Prostate
Cystoscopy
Hyperplasia
Middle Aged
medicine.disease
Instillation, Drug
Treatment Outcome
Overactive bladder
050211 marketing
International Prostate Symptom Score
business
Gels
Subjects
Details
- ISSN :
- 1464410X
- Volume :
- 125
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BJU internationalReferences
- Accession number :
- edsair.doi.dedup.....ac94e3622730055929cc9ef08b7ee4e4