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Quality of Life and Disability in Patients with Treatment-Failure Gout
- Source :
- The Journal of Rheumatology. 36:1041-1048
- Publication Year :
- 2009
- Publisher :
- The Journal of Rheumatology, 2009.
-
Abstract
- Objective.The relationship between self-reported quality of life and disability and disease severity was evaluated in subjects with treatment-failure gout (n = 110) in a prospective, 52-week, observational study.Methods.Subjects had symptomatic crystal-proven gout of at least 2 years’ duration and intolerance or refractoriness to conventional urate-lowering therapy. Serum uric acid (sUA) concentration, swollen and tender joint counts, frequency and severity of gout flares, tophus assessments, comorbidities, and patient-reported outcomes data [Medical Outcomes Study Short Form-36 (SF-36), Health Assessment Questionnaire-Damage Index] were collected. Analyses included correlations of patient-reported outcomes with clinical variables and changes in clinical status.Results.Mean age of study subjects was 59 years. Mean scores on SF-36 physical functioning subscales were 34.2–46.8, analogous to persons aged ≥ 75 years in the general population. Subjects with more severe gout at baseline had worse health-related quality of life (HRQOL) in all areas (p < 0.02 for all measures), compared to patients with mild-moderate disease. Number of flares reported in past year, number of tender joints, swollen joints, and tophi correlated significantly with some or all HRQOL and disability measures. sUA was not significantly correlated with any HRQOL or disability measure. Subjects with comorbidities experienced worse physical, but not mental, functioning.Conclusion.Severe gout is associated with poor HRQOL and disability, especially for patients who experience more gout flares and have a greater number of involved joints. Subject perceptions of gout-related functioning and pain severity appear to be highly sensitive indicators of HRQOL and disability.
- Subjects :
- Male
musculoskeletal diseases
Self-Assessment
medicine.medical_specialty
Gout
Health Status
Immunology
Population
Severity of Illness Index
Gout Suppressants
Disability Evaluation
Rheumatology
Quality of life
Recurrence
Internal medicine
Activities of Daily Living
Severity of illness
medicine
Humans
Immunology and Allergy
Prospective Studies
Treatment Failure
Hyperuricemia
education
education.field_of_study
business.industry
Tophus
Middle Aged
medicine.disease
Pegloticase
Quality of Life
Physical therapy
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 14992752 and 0315162X
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- The Journal of Rheumatology
- Accession number :
- edsair.doi.dedup.....ac8b29cc215b34481dea56bcf821353c