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Long term follow-up study to evaluate immunogenicity and safety of a single dose of live attenuated hepatitis a vaccine in children
- Source :
- Human Vaccines & Immunotherapeutics
- Publication Year :
- 2015
- Publisher :
- Informa UK Limited, 2015.
-
Abstract
- Worldwide, viral hepatitis continues to be a cause of considerable morbidity and mortality. Mass immunization with a single dose of live attenuated HAV has been shown to significantly reduce disease burden in the community. This was a phase IV, 5-year follow up study carried out at 4 centers (Kolkata, Delhi, Mumbai and Chennai) across India. The subjects with antibody titer 20 mIU/mL). The seroconversion rates considering seroprotection levels of anti-HAV antibody titer >20 mIU/mL, following vaccination starting from 6 weeks, 6 months, 12 months, 24 months, 36 months, 48 months and 60 months were 95.1%, 97.9%, 98.3%, 96.2%, 97.8%, 92.6% and 97.3%, respectively. The geometric mean concentration (GMC) over the years increased from 64.9 mIU/mL at 6 weeks to 38.1 mIU/mL and 135.2 mIU/mL at 6 months and 12 months, respectively and was maintained at 127.1 mIU/mL at 60 months. In conclusion, the result of this 5-year follow up study showed that the single dose of live attenuated vaccine is well tolerated and provides long-term immunogenicity in healthy Indian children.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Immunology
Hepatitis A vaccine
India
immunization
Hepatitis A Antibodies
children
antibody
medicine
Humans
Immunology and Allergy
Seroconversion
Child
Pharmacology
live attenuated vaccine
Hepatitis A Vaccines
Attenuated vaccine
business.industry
Immunogenicity
Antibody titer
Infant
Hepatitis A
medicine.disease
Surgery
Vaccination
Child, Preschool
Female
Viral hepatitis
business
Research Paper
Follow-Up Studies
Subjects
Details
- ISSN :
- 2164554X and 21645515
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Human Vaccines & Immunotherapeutics
- Accession number :
- edsair.doi.dedup.....ac7f63fb56cdd2d3e0dd4da4ce9fa1e6