Back to Search
Start Over
Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome
- Source :
- Scandinavian journal of rheumatology. 26(4)
- Publication Year :
- 1997
-
Abstract
- Twelve outpatients, all women, who fulfilled the criteria for both fibromyalgia and chronic fatigue syndrome were rated on 15 items of the Comprehensive Psychopathological Rating Scale (CPRS-15). These items were chosen to constitute a proper neurasthenic subscale. Blood laboratory levels were generally normal. The most obvious finding was that, in all the patients, the homocysteine (HCY) levels were increased in the cerebrospinal fluid (CSF). There was a significant positive correlation between CSF-HCY levels and fatiguability, and the levels of CSF-B12 correlated significantly with the item of fatiguability and with CPRS-15. The correlations between vitamin B12 and clinical variables of the CPRS-scale in this study indicate that low CSF-B12 values are of clinical importance. Vitamin B12 deficiency causes a deficient remethylation of HCY and is therefore probably contributing to the increased homocysteine levels found in our patient group. We conclude that increased homocysteine levels in the central nervous system characterize patients fulfilling the criteria for both fibromyalgia and chronic fatigue syndrome.
- Subjects :
- Adult
medicine.medical_specialty
Fibromyalgia
Homocysteine
Immunology
Comprehensive Psychopathological Rating Scale
Gastroenterology
Models, Biological
chemistry.chemical_compound
Cerebrospinal fluid
Cystathionine
Methionine
Rheumatology
Internal medicine
Chronic fatigue syndrome
medicine
Immunology and Allergy
Humans
Vitamin B12
Cyanocobalamin
Fatigue Syndrome, Chronic
business.industry
General Medicine
Middle Aged
medicine.disease
Vitamin B 12
chemistry
Physical therapy
Fatiguability
Female
business
Subjects
Details
- ISSN :
- 03009742
- Volume :
- 26
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Scandinavian journal of rheumatology
- Accession number :
- edsair.doi.dedup.....ac72f9862b1b537550bc36530b5cc591