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In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations
- Source :
- Acta Pharmaceutica, Vol 68, Iss 3, Pp 373-380 (2018), Acta Pharmaceutica, Volume 68, Issue 3
- Publication Year :
- 2018
- Publisher :
- Sciendo, 2018.
-
Abstract
- The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan-induced hyperalgesia, combined with a test with a mechanical stimulus, and a hot plate test. Rats were divided into seven groups (n = 6) and received local treatment with two peat formulations and two diclofenac formulations dissolved in carbopol gel and Wolff® basis creme, respectively. Carbopol gel, Wolff® basis creme and 0.9 % NaCl without tested substances were used as controls. Both peat formulations exerted an unambiguous antihyperalgesic effect 60 minutes after the treatment. In the hot plate test, the rats treated with the Wolff® basis creme peat formulation showed a tendency to prolonged latency on the first hour. The results could be explained by partial activation of peripheral α2-adrenoceptors and the possible COX-2 suppressive activity.
- Subjects :
- Male
Peat
Diclofenac
Time Factors
Acrylic Resins
Pharmaceutical Science
Carrageenan
peat
hyperalgesia
Wistar rats
03 medical and health sciences
Soil
0302 clinical medicine
In vivo
Receptors, Adrenergic, alpha-2
medicine
Animals
Cyclooxygenase Inhibitors
Hot plate test
Rats, Wistar
Pharmaceutical industry
Pharmacology
Analgesics
Chromatography
Cyclooxygenase 2 Inhibitors
Chemistry
wistar rats
General Medicine
Rats
Disease Models, Animal
Nociception
030220 oncology & carcinogenesis
Hyperalgesia
medicine.symptom
HD9665-9675
Gels
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 18469558 and 13300075
- Volume :
- 68
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Acta Pharmaceutica
- Accession number :
- edsair.doi.dedup.....ac669d277935af1a909d53bcb76ccc03