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The Regulatory Roles of Long Non-Coding RNA in the Chemoresistance Process of Ovarian cancer
- Source :
- Current pharmaceutical design. 25(8)
- Publication Year :
- 2018
-
Abstract
- Background: Ovarian cancer is the most malignant tumor in gynecological tumors, with low five-year survival rate. The main reasons are diagnosis at advanced stages (the early symptoms are uncharacteristic, and most are diagnosedlate.), relapse, and resistance to existing chemotherapy drugs. Methods: Search strategy was performed in the following steps. Firstly, LncRNA related to ovarian cancer was retrieved by using the LncRNA Disease database, and articles were searched by searching keywords: ovarian cancer, drug resistance, and LncRNA retrieved from the LncRNA Disease database. Results/Conclusion: With the development of the study on drug resistance of ovarian cancer, the role of LncRNAs as sensitive biomarker and therapeutic target has emerged, providing a direction for precision medicine of ovarian cancer resistance.
- Subjects :
- Oncology
medicine.medical_specialty
Disease
Drug resistance
01 natural sciences
03 medical and health sciences
Internal medicine
Drug Discovery
medicine
Biomarkers, Tumor
Humans
Survival rate
030304 developmental biology
Pharmacology
Ovarian Neoplasms
0303 health sciences
business.industry
Advanced stage
Precision medicine
medicine.disease
Long non-coding RNA
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Drug Resistance, Neoplasm
Biomarker (medicine)
Female
RNA, Long Noncoding
Neoplasm Recurrence, Local
Ovarian cancer
business
Subjects
Details
- ISSN :
- 18734286
- Volume :
- 25
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Current pharmaceutical design
- Accession number :
- edsair.doi.dedup.....ac5ea0afc452014310d78cac8b3efc83