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UV light-induced reactivation of herpes simplex virus type 2 and prevention by acyclovir
- Source :
- The Journal of infectious diseases. 166(3)
- Publication Year :
- 1992
-
Abstract
- UV B light is a potent stimulus for inducing reactivation of latent herpes simplex virus (HSV) infections. Patients were enrolled in a double-blind placebo-controlled crossover trial to determine whether acyclovir can prevent UV light-induced HSV-2 recurrences. Twenty-four patients with a history of recurrent infection of perigenital sites (e.g., buttock, thigh) were exposed one to four times with 4 minimum erythema doses of UV light. Patients were given acyclovir 200 mg orally five times daily or matched placebo beginning 1 day before each exposure and continuing for 5 days after exposure. There were 13 UV-induced recurrences among 36 placebo treatments and 3 after 38 acyclovir treatments (P = .004). The mean time to recurrence (+/- SE) was 4.8 +/- 0.3 days. HSV-2 lesions developed primarily at the site of UV exposure. The cutaneous distribution and timing of UV-induced recurrences was consistent with a neural localization (dorsal root ganglia) of latent viral infection. This UV light model permits direct examination of events leading to HSV-2 recurrences in humans and can be used to evaluate approaches to prevention.
- Subjects :
- Adult
Male
medicine.medical_specialty
Erythema
Adolescent
Ultraviolet Rays
Acyclovir
Biology
Placebo
medicine.disease_cause
Gastroenterology
Virus
Herpesviridae
Double-Blind Method
Internal medicine
Alphaherpesvirinae
medicine
Immunology and Allergy
Humans
Simplexvirus
Aciclovir
Herpes Simplex
Middle Aged
biology.organism_classification
Crossover study
Infectious Diseases
Herpes simplex virus
Immunology
Female
Virus Activation
medicine.symptom
medicine.drug
Subjects
Details
- ISSN :
- 00221899
- Volume :
- 166
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Journal of infectious diseases
- Accession number :
- edsair.doi.dedup.....ac569c1c9a169eec7276cbcbac91c43b