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Phenprocoumon-induced hepatitis mimicking non-A, non-B hepatitis
- Source :
- Journal of Hepatology. 11:318-321
- Publication Year :
- 1990
- Publisher :
- Elsevier BV, 1990.
-
Abstract
- A 58-year-old man presented with jaundice 6 months after aortic valve replacement. Although non-A, non-B hepatitis was initially suspected, the final diagnosis of phenprocoumon (Marcoumar)-induced hepatitis progressing to cirrhosis was based on recurrence of jaundice after re-exposure to the drug, improvement after withdrawal and centrilobular necrosis with eosinophilic infiltration in the liver biopsy. Antibodies to hepatitis C virus were absent. The aortic valve was replaced by a bioprosthesis to eliminate the need for life-long anticoagulation.
- Subjects :
- Male
medicine.medical_specialty
Pathology
Cirrhosis
Hepatitis C virus
Hepacivirus
Antibodies, Viral
medicine.disease_cause
Gastroenterology
Diagnosis, Differential
Phenprocoumon
Aortic valve replacement
Thromboembolism
Internal medicine
Humans
Medicine
Hepatitis
Hepatology
medicine.diagnostic_test
business.industry
Centrilobular necrosis
Middle Aged
Jaundice
medicine.disease
Hepatitis C
Liver
Liver biopsy
Chemical and Drug Induced Liver Injury
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 01688278
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Hepatology
- Accession number :
- edsair.doi.dedup.....ac4aef3468f1a4cf18a157ff74023c80
- Full Text :
- https://doi.org/10.1016/0168-8278(90)90214-c