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Phenprocoumon-induced hepatitis mimicking non-A, non-B hepatitis

Authors :
F.J.W. ten Kate
J. H. P. Wilson
R.A. de Man
S.W. Schalm
E. van Leer
Source :
Journal of Hepatology. 11:318-321
Publication Year :
1990
Publisher :
Elsevier BV, 1990.

Abstract

A 58-year-old man presented with jaundice 6 months after aortic valve replacement. Although non-A, non-B hepatitis was initially suspected, the final diagnosis of phenprocoumon (Marcoumar)-induced hepatitis progressing to cirrhosis was based on recurrence of jaundice after re-exposure to the drug, improvement after withdrawal and centrilobular necrosis with eosinophilic infiltration in the liver biopsy. Antibodies to hepatitis C virus were absent. The aortic valve was replaced by a bioprosthesis to eliminate the need for life-long anticoagulation.

Details

ISSN :
01688278
Volume :
11
Database :
OpenAIRE
Journal :
Journal of Hepatology
Accession number :
edsair.doi.dedup.....ac4aef3468f1a4cf18a157ff74023c80
Full Text :
https://doi.org/10.1016/0168-8278(90)90214-c