Back to Search
Start Over
Immunobiology of haematological malignant disorders: the basis for novel immunotherapy protocols
- Source :
- The Lancet Oncology. 5:47-55
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- The immune system is a complex arrangement of cellular interactions that preserve the integrity of a organism by elimination of all elements judged dangerous. However, the development of tumours in immunocompetent patients suggests the existence of an imbalance that favours tumour cells against the immune response. What are the different possibilities for reversing this process to drive an efficient antitumour response? We discuss, focusing on the haematological features, classic immunity (ie, antigen-specific and HLA-restricted immunity). We address the central issues of tumour antigen presentation and recognition and their possible clinical use. Last, we discuss non-HLA-restricted immunity, which does not require the recognition of specific antigens and relies on particular cell populations such as natural killer cells.
- Subjects :
- Tumour antigen
business.industry
medicine.medical_treatment
chemical and pharmacologic phenomena
Immunotherapy
biochemical phenomena, metabolism, and nutrition
Killer Cells, Natural
Immune system
Oncology
Antigen
Antigens, Neoplasm
Immunity
Hematologic Neoplasms
Immunology
Humans
Medicine
business
Organism
Subjects
Details
- ISSN :
- 14702045
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- The Lancet Oncology
- Accession number :
- edsair.doi.dedup.....ac475c154bf01b51db115ad4d73c8c82