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Ptf1a function and transcriptional cis‐regulation, a cornerstone in vertebrate pancreas development
- Source :
- The FEBS Journal. 289:5121-5136
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Vertebrate pancreas organogenesis is a stepwise process regulated by a complex network of signaling and transcriptional events, progressively steering the early endoderm toward pancreatic fate. Many crucial players of this process have been identified, including signaling pathways, cis-regulatory elements, and transcription factors (TFs). Pancreas-associated transcription factor 1a (PTF1A) is one such TF, crucial for pancreas development. PTF1A mutations result in dramatic pancreatic phenotypes associated with severe complications, such as neonatal diabetes and impaired food digestion due to exocrine pancreatic insufficiency. Here, we present a brief overview of vertebrate pancreas development, centered on Ptf1a function and transcriptional regulation, covering similarities and divergences in three broadly studied organisms: human, mouse and zebrafish.
- Subjects :
- Organogenesis
Gene Expression Regulation, Developmental
Cell Biology
Biology
medicine.disease
biology.organism_classification
Biochemistry
Phenotype
Cell biology
Mice
medicine.anatomical_structure
medicine
Transcriptional regulation
Animals
Humans
Endoderm
Pancreas
Exocrine pancreatic insufficiency
Molecular Biology
Transcription factor
Zebrafish
Transcription Factors
Subjects
Details
- ISSN :
- 17424658 and 1742464X
- Volume :
- 289
- Database :
- OpenAIRE
- Journal :
- The FEBS Journal
- Accession number :
- edsair.doi.dedup.....ac4691518ea20eb803f32d186faf6c87