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Ifosfamide-induced neurotoxicity
- Source :
- Gynecologic Oncology. 42:193-196
- Publication Year :
- 1991
- Publisher :
- Elsevier BV, 1991.
-
Abstract
- Ifosfamide is an active chemotherapeutic agent in a wide range of gynecologic tumors; favorable response rates have been reported in ovarian (epithelial and germ cell), uterine, and cervical neoplasms. Central neurotoxicity is a known, but poorly described side effect. We report 23 patients who received a total of 75 cycles of ifosfamide, either as a single agent or in combination with other chemotherapeutic agents. Six of twenty-three (26%) experienced grade 4 neurotoxicity; clinical presentation included confusion, aphasia, hallucinations, and coma. All patients exhibited the first evidence of neurotoxicity by the end of the 24-hr infusion. Three of six patients with grade 4 neurotoxicity expired within 14 days of receiving ifosfamide. The neurotoxicity resolved over 2 to 4 days in the remaining patients. Serum albumin was normal (greater than 3.5 g/dl) in 63 cycles of ifosfamide not associated with neurotoxicity. When serum albumin was less than 3.5 g/dl, 6 of 12 cycles were associated with severe neurotoxicity (P less than 0.001). Low serum albumin (less than 3.5 g/dl) appears to be associated with a high risk of severe neurotoxicity in patients receiving single-dose ifosfamide therapy.
- Subjects :
- Adult
Central Nervous System
medicine.medical_specialty
Side effect
Genital Neoplasms, Female
Serum albumin
Pharmacology
Gastroenterology
Drug Administration Schedule
Risk Factors
Internal medicine
Humans
Medicine
In patient
Ifosfamide
Serum Albumin
Aged
Coma
biology
business.industry
Neurotoxicity
Obstetrics and Gynecology
Middle Aged
medicine.disease
Oncology
Creatinine
Toxicity
biology.protein
Female
medicine.symptom
business
Low serum albumin
medicine.drug
Subjects
Details
- ISSN :
- 00908258
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Gynecologic Oncology
- Accession number :
- edsair.doi.dedup.....ac420b75c4f66f61e31ade2d519ee8c4