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Preferential loss of maternal 9p alleles in childhood acute lymphoblastic leukemia

Authors :
Anthony E. Reeve
Lochie Teague
Lana M. Ellis
Ian M. Morison
Source :
Blood. 99:375-377
Publication Year :
2002
Publisher :
American Society of Hematology, 2002.

Abstract

Germ-line events, such as paternal mutation or genomic imprinting, contribute to the early onset of childhood cancers such as retinoblastoma, Wilms tumors, and neuroblastoma. Given the high frequency of deletion involving chromosome 9p in childhood acute lymphoblastic leukemia (ALL), this study investigated whether 9p deletion might reflect preexisting germ-line gene inactivation. To do this the parental origin of deletion was determined in 10 cases of ALL with 9p21 loss of heterozygosity. Of these cases, 9 showed loss of the maternally derived allele, suggesting that a germ-line event involving a 9p gene may play a role in the onset of childhood ALL.

Details

ISSN :
15280020 and 00064971
Volume :
99
Database :
OpenAIRE
Journal :
Blood
Accession number :
edsair.doi.dedup.....ac3ad26162d8c095b70a69d45765aac6
Full Text :
https://doi.org/10.1182/blood.v99.1.375