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Preferential loss of maternal 9p alleles in childhood acute lymphoblastic leukemia
- Source :
- Blood. 99:375-377
- Publication Year :
- 2002
- Publisher :
- American Society of Hematology, 2002.
-
Abstract
- Germ-line events, such as paternal mutation or genomic imprinting, contribute to the early onset of childhood cancers such as retinoblastoma, Wilms tumors, and neuroblastoma. Given the high frequency of deletion involving chromosome 9p in childhood acute lymphoblastic leukemia (ALL), this study investigated whether 9p deletion might reflect preexisting germ-line gene inactivation. To do this the parental origin of deletion was determined in 10 cases of ALL with 9p21 loss of heterozygosity. Of these cases, 9 showed loss of the maternally derived allele, suggesting that a germ-line event involving a 9p gene may play a role in the onset of childhood ALL.
- Subjects :
- Immunology
Loss of Heterozygosity
Mothers
Cell Cycle Proteins
Biology
medicine.disease_cause
Polymerase Chain Reaction
Biochemistry
Loss of heterozygosity
Acute lymphocytic leukemia
Neuroblastoma
medicine
Humans
Genes, Tumor Suppressor
Genetic Predisposition to Disease
Allele
Child
Childhood Acute Lymphoblastic Leukemia
Alleles
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p15
Mutation
Retinoblastoma
Tumor Suppressor Proteins
Infant
Sequence Analysis, DNA
Cell Biology
Hematology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Child, Preschool
Female
Chromosomes, Human, Pair 9
Genomic imprinting
Gene Deletion
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi.dedup.....ac3ad26162d8c095b70a69d45765aac6
- Full Text :
- https://doi.org/10.1182/blood.v99.1.375