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N-Cadherin and M-Cadherin are sequentially expressed in myoblast populations contributing to the first and second waves of myogenesis in the trout (Oncorhynchus mykiss)
- Source :
- Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Wiley, 2012, 318B (1), pp.71-77. ⟨10.1002/jez.b.21443⟩
- Publication Year :
- 2012
- Publisher :
- HAL CCSD, 2012.
-
Abstract
- The objective of this study was to investigate the expression of two promyogenic cell surface adhesion receptors, N- and M-cadherin, in developing trout (Oncorhynchus mykiss) somite, taking account of the recent identification of a dermomyotome-like epithelium in teleosts. In situ hybridization showed that N-cadherin was expressed throughout the paraxial mesoderm and nascent somite. As the somite matured, N-cadherin expression disappeared ventrally from the sclerotome, and then mediolaterally from the differentiating slow and fast muscle cells of the embryonic myotome, to become finally restricted to the undifferentiated myogenic precursors forming the dermomyotome-like epithelium that surrounds the embryonic myotome. By contrast, M-cadherin, which was transcribed in the differentiating embryonic myotome, was never expressed in the dermomyotome-like epithelium. In late-stage trout embryos, M-cadherin transcript was only detected at the periphery of the expanding myotome, where muscle cells stemming from the N-cadherin positive dermomyotome-like epithelium differentiate. Collectively, our results support the view that, in trout embryo, N-cadherin is associated with muscle cell immaturity while M-cadherin is associated with muscle cell maturation and differentiation and this during the two successive phases of myogenesis. J. Exp. Zool. (Mol. Dev. Evol.) 318:71-77, 2012. (C) 2011 Wiley Periodicals, Inc.
- Subjects :
- medicine.medical_specialty
animal structures
Cellular differentiation
[SDV]Life Sciences [q-bio]
Biology
Muscle Development
Epithelium
Myoblasts
03 medical and health sciences
0302 clinical medicine
Myotome
Internal medicine
Genetics
medicine
Paraxial mesoderm
Myocyte
Animals
Ecology, Evolution, Behavior and Systematics
030304 developmental biology
0303 health sciences
Myogenesis
Cadherin
Gene Expression Profiling
Gene Expression Regulation, Developmental
Cell Differentiation
HISTOLOGIE
Cadherins
Embryonic stem cell
Cell biology
Somite
medicine.anatomical_structure
Endocrinology
cadherin
Somites
Oncorhynchus mykiss
Molecular Medicine
Animal Science and Zoology
030217 neurology & neurosurgery
Developmental Biology
SALMONIDE
Subjects
Details
- Language :
- English
- ISSN :
- 15525007 and 15525015
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Wiley, 2012, 318B (1), pp.71-77. ⟨10.1002/jez.b.21443⟩
- Accession number :
- edsair.doi.dedup.....ac1b01eb9d2cb167a2e95c5a499175a0
- Full Text :
- https://doi.org/10.1002/jez.b.21443⟩