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Epileptic seizures in autosomal dominant forms of Alzheimer’s disease
- Source :
- Seizure. 61:4-7
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder and represents the most common form of dementia in the elderly. Mutations in genes encoding presenilin 1 (PSEN1), presenilin 2 (PSEN2) and amyloid precursor protein (APP) are responsible for early-onset familial AD (EOFAD). Several pieces of evidence report that patients with rare autosomal dominant forms of AD carry a significant risk to develop seizures. However, the molecular mechanisms linking epilepsy and AD are needed to be clarified: the pathophysiology of seizures in AD may be related to an increased production of amyloid-β (Aβ) peptide or structural alterations in neurons probably due to cerebrovascular changes, neurotransmitter or cytoskeletal dysfunctions. Seizures have traditionally been related to neuronal loss in the late stages of AD as a consequence of neurodegeneration, however, recent studies indicated that seizures may contribute to the emergence of AD symptoms in early stages of the disease, mainly in familial AD. So, a better understanding of possible common neural mechanisms might help to improve the clinical management of both conditions. This review aims to give a comprehensive overview and to analyze the association between epilepsy and EOFAD, focusing on possible overlapping pathological mechanisms.
- Subjects :
- 0301 basic medicine
Disease
Presenilin
Amyloid beta-Protein Precursor
03 medical and health sciences
Epilepsy
0302 clinical medicine
Genetic
Alzheimer Disease
Seizures
Presenilin-2
PSEN2
Presenilin-1
PSEN1
Amyloid precursor protein
Humans
Medicine
Dementia
biology
business.industry
Neurodegeneration
General Medicine
Alzheimer's disease
medicine.disease
Seizure
030104 developmental biology
Neurology
Mutation
biology.protein
Neurology (clinical)
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10591311
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Seizure
- Accession number :
- edsair.doi.dedup.....ac0ff99b5f803fdfc6bd4c007c25f076