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A study of the histological criteria for ulcerative colitis: Retrospective evaluation of multiple colonic biopsies
- Source :
- Journal of Gastroenterology. 30:189-194
- Publication Year :
- 1995
- Publisher :
- Springer Science and Business Media LLC, 1995.
-
Abstract
- It is clinically important to distinguish idiopathic inflammatory bowel disease (IBD) from other colitides, and ulcerative colitis (UC) from Crohn's disease (CD); however only a few histological criteria based on colonic biopsies have been established. We investigated 209 consecutive series of biopsies taken from 38 patients with UC, 12 with CD, and 105 with other colitides, to evaluate whether combinations of histological features, selected on the basis of our experience, and listed below, could be useful criteria for the differential diagnosis of IBD, and, more specifically, of UC: (A) chronic inflammation with a predominant increase of plasma cells, (B) crypt distortion, (C) crypt atrophy, (D) diffuse chronic inflammation within a biopsy and between biopsies, and (E) diffuse mucin depletion within a biopsy and between biopsies. Findings that fulfilled all or two of A-C distinguished IBD from the other colitides with high sensitivity (94.3%) and specificity (95.8%). When the findings fulfilled the additional criteria of D and/or E, UC was differentiated from CD or the other colitides with high sensitivity (86.4%) and specificity (99.3%).
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Adolescent
Biopsy
Sensitivity and Specificity
Inflammatory bowel disease
Gastroenterology
Diagnosis, Differential
Atrophy
Crohn Disease
Surgical oncology
Internal medicine
medicine
Humans
Child
Aged
Retrospective Studies
Aged, 80 and over
medicine.diagnostic_test
business.industry
Middle Aged
Hepatology
Inflammatory Bowel Diseases
medicine.disease
Ulcerative colitis
digestive system diseases
Colorectal surgery
Colitis, Ulcerative
Female
Differential diagnosis
business
Subjects
Details
- ISSN :
- 14355922 and 09441174
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....abf0f1118c850f3d21c0a52be9bbb8b6
- Full Text :
- https://doi.org/10.1007/bf02348664