Radiomics analysis based on multiple parameters MR imaging in the spine: Predicting treatment response of osteolytic bone metastases to chemotherapy in breast cancer patients

To assess the value of radiomics, apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM) and stretched-exponential (SE) MR imaging in prediction of therapeutic response in patients with spinal metastases before chemotherapy.Thirty-six patients with 190 osteolytic metastatic lesions from breast cancer were prospectively enrolled and underwent MR imaging before and after 6 months' treatment on a 1.5 T MRI. According to MDA criteria, 68 lesions were categorized as progressive disease (PD) and 122 lesions were categorized as stable or improvement (non-PD). The regions of interest (ROIs) were manually drawn on DWI, T1WI, T2WI and FS-T2WI by two radiologists with ITK-SNAP. The ADCThe mean values of ADC, DDC, and D before treatment were significantly higher in non-PD group than those in PD group (P = 0.001). The radiomics based on ADCRadiomics model based on ADC