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Caffeine attenuates brain injury but increases mortality induced by high-intensity blast wave exposure
- Source :
- Toxicology Letters. 301:90-97
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Caffeine is a substance that is consumed worldwide, and it may exert neuroprotective effects against various cerebral insults, including neurotrauma, which is the most prevalent injury among military personnel. To investigate the effects of caffeine on high-intensity blast wave-induced severe blast injury in mice, three different paradigms of caffeine were applied to male C57BL/6 mice with severe whole body blast injury (WBBI). The results demonstrated that chronic caffeine treatment alleviated blast-induced traumatic brain injury (bTBI); however, both chronic and acute caffeine treatments exacerbated blast-induced lung injuries and, more importantly, increased both the cumulative and time-segmented mortalities postinjury. Interestingly, withdrawing caffeine intake preinjury resulted in favorable outcomes in mortality and lung injury, similar to the findings in water-treated mice, and had the trend to attenuate brain injury. These findings demonstrated that although drinking coffee or caffeine preparations attenuated blast-induced brain trauma, these beverages may place personnel in the battlefield at high risk of casualties, which will help us re-evaluate the therapeutic strategy of caffeine application, particularly in multiple-organ-trauma settings. Furthermore, these findings provided possible strategies for reducing the risk of casualties with caffeine consumption, which may help to change the coffee-drinking habits of military personnel.
- Subjects :
- Male
0301 basic medicine
Traumatic brain injury
Physiology
Poison control
Lung injury
Toxicology
Neuroprotection
Blast injury
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Blast Injuries
Caffeine
Brain Injuries, Traumatic
Injury prevention
medicine
Animals
business.industry
Major trauma
General Medicine
medicine.disease
Mice, Inbred C57BL
Disease Models, Animal
Neuroprotective Agents
030104 developmental biology
chemistry
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 03784274
- Volume :
- 301
- Database :
- OpenAIRE
- Journal :
- Toxicology Letters
- Accession number :
- edsair.doi.dedup.....abe6df947a6a282754d5d0d1d4953b89