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The Transcription Factor RORα Preserves ILC3 Lineage Identity and Function during Chronic Intestinal Infection
- Source :
- Journal of immunology (Baltimore, Md. : 1950). 203(12)
- Publication Year :
- 2019
-
Abstract
- Innate lymphoid cells (ILCs) are critical for host defense and tissue repair but can also contribute to chronic inflammatory diseases. The transcription factor RORα is required for ILC2 development but is also highly expressed by other ILC subsets where its function remains poorly defined. We previously reported that Rorasg/sg bone marrow chimeric mice (C57BL/6J) were protected from Salmonella-induced intestinal fibrosis due to defective ILC3 responses. In this study, single-cell RNA analysis of ILCs isolated from inflamed tissues indicates that RORα perturbation led to a reduction in ILC3 lineages. Furthermore, residual Rorasg/sg ILC3s have decreased expression of key signature genes, including Rorc and activating cytokine receptors. Collectively, our data suggest that RORα plays a key role in preserving functional ILC3s by modulating their ability to integrate environmental cues to efficiently produce cytokines.
- Subjects :
- Lymphoid Tissue
medicine.medical_treatment
Immunology
Biology
03 medical and health sciences
Mice
0302 clinical medicine
Immunity
RAR-related orphan receptor gamma
Fibrosis
medicine
Immunology and Allergy
Animals
Lymphocytes
Receptor
Gene
Transcription factor
Innate lymphoid cell
Nuclear Receptor Subfamily 1, Group F, Member 1
medicine.disease
Enteritis
Immunity, Innate
Cell biology
Disease Models, Animal
Cytokine
Chronic Disease
Biomarkers
030215 immunology
Subjects
Details
- ISSN :
- 15506606
- Volume :
- 203
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Accession number :
- edsair.doi.dedup.....abe17d77da501a0091c86ddd5ce1462e