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Comparative acoustic performance and mechanical properties of silk membranes for the repair of chronic tympanic membrane perforations
- Source :
- Journal of the mechanical behavior of biomedical materials. 64
- Publication Year :
- 2016
-
Abstract
- The acoustic and mechanical properties of silk membranes of different thicknesses were tested to determine their suitability as a repair material for tympanic membrane perforations. Membranes of different thickness (10-100μm) were tested to determine their frequency response and their resistance to pressure loads in a simulated ear canal model. Their mechanical rigidity to pressure loads was confirmed by tensile testing. These membranes were tested alongside animal cartilage, currently the strongest available myringoplasty graft as well as paper, which is commonly used for simpler procedures. Silk membranes showed resonant frequencies within the human hearing range and a higher vibrational amplitude than cartilage, suggesting that silk may offer good acoustic energy transfer characteristics. Silk membranes were also highly resistant to simulated pressure changes in the middle ear, suggesting they can resist retraction, a common cause of graft failure resulting from chronic negative pressures in the middle ear. Part of this strength can be explained by the substantially higher modulus of silk films compared with cartilage. This allows for the production of films that are much thinner than cartilage, with superior acoustic properties, but that still provide the same level of mechanical support as thicker cartilage. Together, these in vitro results suggest that silk membranes may provide good hearing outcomes while offering similar levels of mechanical support to the reconstructed middle ear.
- Subjects :
- Materials science
Perforation (oil well)
Biomedical Engineering
Silk
Fibroin
Biocompatible Materials
7. Clean energy
Biomaterials
03 medical and health sciences
Myringoplasty
0302 clinical medicine
otorhinolaryngologic diseases
medicine
Animals
Humans
Ear canal
Composite material
030223 otorhinolaryngology
Tympanic Membrane Perforation
Cartilage
fungi
Acoustics
medicine.anatomical_structure
Membrane
Mechanics of Materials
Middle ear
sense organs
030217 neurology & neurosurgery
Biomedical engineering
Subjects
Details
- ISSN :
- 18780180
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Journal of the mechanical behavior of biomedical materials
- Accession number :
- edsair.doi.dedup.....abcb367d3c4268324754c738ffe81d3f