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Audiological findings in a Phase I protocol investigating the effect of WR 2721, high-dose cisplatin and radiation therapy in patients with locally advanced cervical carcinoma
- Source :
- The Journal of Laryngology & Otology. 109:744-747
- Publication Year :
- 1995
- Publisher :
- Cambridge University Press (CUP), 1995.
-
Abstract
- WR 2721 (ethiofos) protects against the toxic effects of the heavy metal compound cisplatin. which is used in the treatment of solid tumours. In a Phase I protocol designed to determine the maximum dose of WR 2721 which could be tolerated when administered in combination with cisplatin and radiation therapy to patients with cervical carcinoma. 11 patients were evaluated by audiologic testing before and after cisplatin WR 2721 administration in an attempt to identify the degree of ototoxicity. Forty-five per cent were noted to have significant hearing threshold changes. predominantly in the high frequencies. There were no significant changes in the speech frequencies in this series. This contrasts with the greater degrees of ototoxicity observed in controls treated in the same way who received cisplatin without WR 2721 protection.
- Subjects :
- Oncology
Radiation-Sensitizing Agents
medicine.medical_specialty
Hearing Loss, Sensorineural
medicine.medical_treatment
Uterine Cervical Neoplasms
Antineoplastic Agents
Radiation-Protective Agents
Amifostine
Audiometry
Ototoxicity
Internal medicine
Carcinoma
Humans
Medicine
Cisplatin
Chemotherapy
Epithelioma
business.industry
Drug Tolerance
General Medicine
medicine.disease
Combined Modality Therapy
Surgery
Radiation therapy
Otorhinolaryngology
Toxicity
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 17485460 and 00222151
- Volume :
- 109
- Database :
- OpenAIRE
- Journal :
- The Journal of Laryngology & Otology
- Accession number :
- edsair.doi.dedup.....abbf1ea679974c6d43afdfecd73fe527