Back to Search
Start Over
Evaluation of Two Rapid Antigenic Tests for the Detection of SARS-CoV-2 in Nasopharyngeal Swabs
- Source :
- Journal of Clinical Medicine, Vol 10, Iss 2774, p 2774 (2021), Journal of Clinical Medicine, Volume 10, Issue 13
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- (1) Background: In the current context of the COVID-19 crisis, there is a need for fast, easy-to-use, and sensitive diagnostic tools in addition to molecular methods. We have therefore decided to evaluate the performance of newly available antigen detection kits in “real-life” laboratory conditions. (2) Methods: The sensitivity and specificity of two rapid diagnostic tests (RDT)—the COVID-19 Ag Respi-Strip from Coris Bioconcept, Belgium (CoRDT), and the coronavirus antigen rapid test cassette from Healgen Scientific, LLC, USA (HeRDT)—were evaluated on 193 nasopharyngeal samples using RT-PCR as the gold standard. (3) Results: The sensitivity obtained for HeRDT was 88% for all collected samples and 91.1% for samples with Ct ≤ 31. For the CoRDT test, the sensitivity obtained was 62% for all collected samples and 68.9% for samples with Ct ≤ 31. (4) Conclusions: Despite the excellent specificity obtained for both kits, the poor sensitivity of the CoRDT did not allow for its use in the rapid diagnosis of COVID-19. HeRDT satisfied the World Health Organization’s performance criteria for rapid antigen detection tests. Its high sensitivity, quick response, and ease of use allowed for the implementation of HeRDT at the laboratory of the University Hospital of Liège.
- Subjects :
- 0303 health sciences
Rapid diagnostic test
Coronavirus disease 2019 (COVID-19)
SARS-CoV-2
030306 microbiology
business.industry
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
COVID-19
Context (language use)
General Medicine
Gold standard (test)
rapid diagnostic test
antigen detection
Diagnostic tools
Virology
Article
World health
03 medical and health sciences
Antigen
Medicine
business
030304 developmental biology
Subjects
Details
- ISSN :
- 20770383
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....abbcb904fcc3653737a90c5f49ead07e
- Full Text :
- https://doi.org/10.3390/jcm10132774