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Histone Variants: Guardians of Genome Integrity

Authors :
Beatrice Rondinelli
Sophie E. Polo
Juliette Ferrand
Centre épigénétique et destin cellulaire (EDC (UMR_7216))
Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
Source :
Cells, Vol 9, Iss 2424, p 2424 (2020), Cells, Cells, MDPI, 2020, 9 (11), pp.2424. ⟨10.3390/cells9112424⟩
Publication Year :
2020
Publisher :
Zenodo, 2020.

Abstract

Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer. Building on these findings, in this review, we discuss how histone variants and their associated chaperones safeguard genome stability and protect against tumorigenesis. Accumulating evidence supports the contribution of histone variants and their chaperones to the maintenance of chromosomal integrity and to various steps of the DNA damage response, including damaged chromatin dynamics, DNA damage repair, and damage-dependent transcription regulation. We present our current knowledge on these topics and review recent advances in deciphering how alterations in histone variant sequence, expression, and deposition into chromatin fuel oncogenic transformation by impacting cell proliferation and cell fate transitions. We also highlight open questions and upcoming challenges in this rapidly growing field.

Details

ISSN :
20734409
Database :
OpenAIRE
Journal :
Cells, Vol 9, Iss 2424, p 2424 (2020), Cells, Cells, MDPI, 2020, 9 (11), pp.2424. ⟨10.3390/cells9112424⟩
Accession number :
edsair.doi.dedup.....abb0866b33dc4ae7105ddbd56488166d
Full Text :
https://doi.org/10.5281/zenodo.4980968