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Histone Variants: Guardians of Genome Integrity
- Source :
- Cells, Vol 9, Iss 2424, p 2424 (2020), Cells, Cells, MDPI, 2020, 9 (11), pp.2424. ⟨10.3390/cells9112424⟩
- Publication Year :
- 2020
- Publisher :
- Zenodo, 2020.
-
Abstract
- Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer. Building on these findings, in this review, we discuss how histone variants and their associated chaperones safeguard genome stability and protect against tumorigenesis. Accumulating evidence supports the contribution of histone variants and their chaperones to the maintenance of chromosomal integrity and to various steps of the DNA damage response, including damaged chromatin dynamics, DNA damage repair, and damage-dependent transcription regulation. We present our current knowledge on these topics and review recent advances in deciphering how alterations in histone variant sequence, expression, and deposition into chromatin fuel oncogenic transformation by impacting cell proliferation and cell fate transitions. We also highlight open questions and upcoming challenges in this rapidly growing field.
- Subjects :
- genome integrity, histones
DNA damage
DNA repair
[SDV]Life Sciences [q-bio]
Cell
Centromere
Review
Biology
Cell fate determination
medicine.disease_cause
DNA damage response
chromosome integrity
Chromosomes
Genomic Instability
Histones
03 medical and health sciences
0302 clinical medicine
medicine
Transcriptional regulation
Animals
Humans
Protein Isoforms
cancer
histone variants
lcsh:QH301-705.5
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
0303 health sciences
cell fate
histone chaperones
General Medicine
oncohistones
Chromatin
Cell biology
medicine.anatomical_structure
Histone
lcsh:Biology (General)
030220 oncology & carcinogenesis
biology.protein
chromatin
Carcinogenesis
genome stability
DNA Damage
Subjects
Details
- ISSN :
- 20734409
- Database :
- OpenAIRE
- Journal :
- Cells, Vol 9, Iss 2424, p 2424 (2020), Cells, Cells, MDPI, 2020, 9 (11), pp.2424. ⟨10.3390/cells9112424⟩
- Accession number :
- edsair.doi.dedup.....abb0866b33dc4ae7105ddbd56488166d
- Full Text :
- https://doi.org/10.5281/zenodo.4980968