Additional file 1 of Impact of a 2-year trial of nutritional ketosis on indices of cardiovascular disease risk in patients with type 2 diabetes

Additional file 1: Figure S1. Change in lipids and lipoprotein subclasses in CCI at baseline, one and two years. Table S1. Baseline characteristics. Table S2. Adjusted means and changes in lipids, blood pressure and CIMT over time by treatment group among completers. Table S3. Lipid lowering and anti-hypertensive medication use over time among completers. Table S4. Adjusted means and changes in lipids, lipoproteins, apoproteins, blood pressure, and CIMT over time by treatment group (intent-to-treat analysis). Table S5. Principal Components and Respective Loading of Each Lipoprotein/Lipid from Baseline and Two-year Follow-up Data. Table S6. Estimated mean proportions and standard errors in the change of LDL phenotype patterns from baseline to two years. Table S7. Multivariate analysis of variance (MANOVA) of lipoprotein subclasses in LDL-C hypo- versus hyper-responders. Table S8. Multivariate analysis of variance (MANOVA) of lipoprotein subclasses in ApoB hypo- versus hyper-responders. Table S9. Relationships between change in BMI and central abdominal fat with lipids and lipoproteins. Table S10. Association between frequency of participants reporting BHB ≥ 0.5mM with change in lipids and lipoproteins from baseline to 2 years. Table S11. LDL phenotype conversions and their associations with frequency of participants reporting BHB ≥ 0.5mM from baseline to 2 years.