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Genetic Variants in EGFR/PLCE1 Pathway Are Associated with Prognosis of Esophageal Squamous Cell Carcinoma after Radical Resection
- Source :
- Current Medical Science. 39:385-390
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Esophageal cancer (EC) is one of the most deadly malignant diseases. Several studies revealed that variations of the phospholipase C epsilon 1 (PLCE1) gene were associated with EC susceptibility. PLCE1 is located downstream of the epidermal growth factor receptor (EGFR) pathway. Presently, the single nucleotide polymorphisms (SNPs) of EGFR/PLCE1 genes and their associations with EC survival remain unclear. In this study, the associations between genetic variants in the EGFR/PLCE1 pathway and prognosis in 124 esophageal squamous cell carcinoma (ESCC) patients with radical resection were explored. The results showed that CC genotype of both PLCE1 rs17109671 and EGFR rs2072454 was associated with ESCC prognosis. Multivariate analysis revealed that patients with the two unfavorable genotypes had the worst overall survival (OS) or disease-free survival (DFS) (HR=6.099, 95%CI=1.903-19.552; HR=3.994, 95%CI=1.49-10.702, respectively). Additionally, combination of SNPs and tumor stage could better predict OS (for AUC, 0.774 vs. 0.709) and PFS (for AUC, 0.773 vs. 0.704) than tumor stage alone. In conclusion, genetic variants of the EGFR/PLCE1 may be predictors of the prognosis of ESCC after surgery. The individuals with the CC genotype of PLCE1 rs17109671 and EGFR rs2072454 should receive more aggressive treatments.
- Subjects :
- Adult
Male
Esophageal Neoplasms
Genotype
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Biochemistry
Esophageal squamous cell carcinoma
Esophagus
Phosphoinositide Phospholipase C
Genetics
Humans
Medicine
Genetic Predisposition to Disease
Epidermal growth factor receptor
Gene
Aged
Neoplasm Staging
Retrospective Studies
PLCE1
biology
business.industry
Genetic variants
Middle Aged
Esophageal cancer
Prognosis
medicine.disease
Survival Analysis
ErbB Receptors
Gene Expression Regulation, Neoplastic
Multivariate Analysis
Cancer research
biology.protein
Female
Esophageal Squamous Cell Carcinoma
business
Signal Transduction
Subjects
Details
- ISSN :
- 2523899X, 20965230, and 17109671
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Current Medical Science
- Accession number :
- edsair.doi.dedup.....ab925d8fc83403ba875fabcd6431d567