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Recombination Activating Genes (RAG) in Lymphoma Development
- Source :
- Cell Cycle. 5:913-916
- Publication Year :
- 2006
- Publisher :
- Informa UK Limited, 2006.
-
Abstract
- The recombination activating genes (RAG) play a central role in the generation of a diverse immune repertoire by mediating DNA recombination events at antigen receptor loci in developing B and T lymphocytes. However, inappropriate RAG activity throughout the genome has been implicated in a large variety of human and mouse lymphomas. Mechanisms by which RAG can provoke or perpetuate lymphoma include deregulation of certain genes by translocation to antigen receptor regulatory regions, the formation of chimeric oncogenes, inactivation of tumor suppressor or micro-RNA loci, or activation of oncogenes. Here we present the T cell receptor enhancer (Ebeta) deficient mouse as a tractable in vivo model system to study the role of RAG activity in the context of lymphoma development, and contrast our system with those of others. We posit a general hypothesis that virtually any mutation that impairs early lymphocyte development at stages when RAG is expressed can constitute a pro-carcinogenic event. Our model system provides a means to assess the roles of RAG activity in human lymphoid malignancies.
- Subjects :
- Lymphoma
Genes, RAG-1
Apoptosis
Mice, Transgenic
Context (language use)
Biology
medicine.disease_cause
Mice
medicine
Animals
Lymphocytes
Enhancer
Molecular Biology
Gene
Genetics
Mutation
Cell Cycle
T-cell receptor
Cell Biology
Genes, p53
medicine.disease
Genes, bcl-2
Cell biology
DNA-Binding Proteins
Regulatory sequence
Genes, T-Cell Receptor beta
Signal transduction
Signal Transduction
Developmental Biology
Subjects
Details
- ISSN :
- 15514005 and 15384101
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Cell Cycle
- Accession number :
- edsair.doi.dedup.....ab845aef343f3317883113813e268647