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Electroacupuncture Regulates Hippocampal Synaptic Plasticity via Inhibiting Janus-Activated Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling in Cerebral Ischemic Rats
- Source :
- Journal of Stroke and Cerebrovascular Diseases. 28:792-799
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- To determine the mechanism(s) involved in electroacupuncture (EA)-mediated improvements in synaptic plasticity in a rat model of middle cerebral artery occlusion and reperfusion (MCAO/R)-induced cognitive deficits.Focal cerebral ischemic stroke was induced by (MCAO/R) surgery. Rats were randomly split into 4 groups: control group (sham operation control), MCAO group, Baihui (GV 20) and Shenting (GV 24) acupoint EA group (verum acupuncture, MCAO + VA), and nonacupoint EA group (control acupuncture, MCAO + CA). EA treatment was administered for 14 consecutive days in MCAO + VA and MCAO + CA groups. Neurological assessment, behavioral performance testing, and molecular biology assays were used to evaluate the MCAO/R model, EA therapeutic effect and potential therapeutic mechanism(s) of EA.Significant amelioration of neurological deficits was found in MCAO + VA rats compared with MCAO rats (P.01). Moreover, learning and memory significantly improved in EA-treated rats compared with MCAO or MCAO + CA rats (P.05) together with an increase in the number of PSD-95EA at GV 20 and GV 24 acupoints improved cognitive deficits in cerebral ischemic rats via the JAK2/STAT3 signaling pathway and mediated synaptic plasticity in the peri-infarct hippocampal CA1 region of rats following ischemic stroke.
- Subjects :
- Male
STAT3 Transcription Factor
Electroacupuncture
animal diseases
medicine.medical_treatment
Pharmacology
Rats, Sprague-Dawley
03 medical and health sciences
Cognition
0302 clinical medicine
Memory
Acupuncture
Animals
Medicine
cardiovascular diseases
Phosphorylation
CA1 Region, Hippocampal
Cognitive deficit
Neuronal Plasticity
Behavior, Animal
Kinase
business.industry
Rehabilitation
Therapeutic effect
Infarction, Middle Cerebral Artery
Recovery of Function
Janus Kinase 2
nervous system diseases
Disease Models, Animal
nervous system
Synaptic plasticity
Ischemic stroke
cardiovascular system
STAT protein
Surgery
Neurology (clinical)
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Acupuncture Points
030217 neurology & neurosurgery
Signal Transduction
Subjects
Details
- ISSN :
- 10523057
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Stroke and Cerebrovascular Diseases
- Accession number :
- edsair.doi.dedup.....ab81c5c6085de3d47770ccf67dc45bd2