Back to Search Start Over

Electroacupuncture Regulates Hippocampal Synaptic Plasticity via Inhibiting Janus-Activated Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling in Cerebral Ischemic Rats

Authors :
Xiao Fan
Jing Tao
Jia Huang
Xiaomin Lin
Weilin Liu
Guanli Xie
Changming Song
Minguang Yang
Lidian Chen
Source :
Journal of Stroke and Cerebrovascular Diseases. 28:792-799
Publication Year :
2019
Publisher :
Elsevier BV, 2019.

Abstract

To determine the mechanism(s) involved in electroacupuncture (EA)-mediated improvements in synaptic plasticity in a rat model of middle cerebral artery occlusion and reperfusion (MCAO/R)-induced cognitive deficits.Focal cerebral ischemic stroke was induced by (MCAO/R) surgery. Rats were randomly split into 4 groups: control group (sham operation control), MCAO group, Baihui (GV 20) and Shenting (GV 24) acupoint EA group (verum acupuncture, MCAO + VA), and nonacupoint EA group (control acupuncture, MCAO + CA). EA treatment was administered for 14 consecutive days in MCAO + VA and MCAO + CA groups. Neurological assessment, behavioral performance testing, and molecular biology assays were used to evaluate the MCAO/R model, EA therapeutic effect and potential therapeutic mechanism(s) of EA.Significant amelioration of neurological deficits was found in MCAO + VA rats compared with MCAO rats (P.01). Moreover, learning and memory significantly improved in EA-treated rats compared with MCAO or MCAO + CA rats (P.05) together with an increase in the number of PSD-95EA at GV 20 and GV 24 acupoints improved cognitive deficits in cerebral ischemic rats via the JAK2/STAT3 signaling pathway and mediated synaptic plasticity in the peri-infarct hippocampal CA1 region of rats following ischemic stroke.

Details

ISSN :
10523057
Volume :
28
Database :
OpenAIRE
Journal :
Journal of Stroke and Cerebrovascular Diseases
Accession number :
edsair.doi.dedup.....ab81c5c6085de3d47770ccf67dc45bd2