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Type 2 Diabetes Mellitus, Dyslipidemia, and Alzheimer's Disease
- Source :
- Journal of Alzheimer's Disease. 20:711-722
- Publication Year :
- 2010
- Publisher :
- IOS Press, 2010.
-
Abstract
- The prevalence of Alzheimer's disease (AD) is increasing rapidly, heightening the importance of finding effective preventive therapies for this devastating disease. Midlife vascular risk factors, including type 2 diabetes mellitus (T2DM), have been associated with increased risk of AD decades later and may serve as targets for AD prevention. Studies to date suggest that T2DM and hyperinsulinemia increase risk for AD, possibly through their effects on amyloid-beta metabolism and cerebrovascular dysfunction - two early findings in preclinical AD pathology. This paper reviews the evidence supporting a relationship between T2DM, hyperinsulinemia, and diabetic dyslipidemia on the development of AD, discusses DM treatment trials and their preliminary results on cognitive function, and proposes some strategies for optimizing future AD prevention trial design.
- Subjects :
- Oncology
medicine.medical_specialty
Blood lipids
Disease
Type 2 diabetes
Vascular risk
Article
Diabetes Complications
Alzheimer Disease
Risk Factors
Internal medicine
Hyperinsulinemia
Animals
Humans
Medicine
Dyslipidemias
business.industry
General Neuroscience
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
General Medicine
medicine.disease
Psychiatry and Mental health
Clinical Psychology
Diabetes Mellitus, Type 2
Immunology
Geriatrics and Gerontology
Alzheimer's disease
business
Dyslipidemia
Subjects
Details
- ISSN :
- 18758908 and 13872877
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's Disease
- Accession number :
- edsair.doi.dedup.....ab7e1b6119a666b4b23501e85c7f7feb